iPTMnet Report for Q93099 (HGD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q93099 / HGD_HUMAN
Protein Name Homogentisate 1,2-dioxygenase
Gene Name Name: HGD
Synonyms:HGO;
Organism Homo sapiens (Human)

PRO ID PR:Q93099
DAG View
PRO Name homogentisate 1,2-dioxygenase (human)
Definition A homogentisate 1,2-dioxygenase that is encoded in the genome of human.
Short Label hHGD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q93099 (HGD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y40 Phosphorylation PhosphoSitePlus
K98 Acetylation PhosphoSitePlus   UniProt 19608861
Y166 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
S296 Phosphorylation HPRD   PhosphoSitePlus 19664995
T302 Phosphorylation HPRD   PhosphoSitePlus 19664995
Y333 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
S416 O-Glycosylation GlyGen 30379171
Y423 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y166 H166 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S296 F296 Biomuta DOID:4159 / skin cancer [ cosmic ]
T302 N302 Biomuta DOID:1324 / lung cancer [ cosmic ]