iPTMnet Report for Q92918 (MAP4K1)
Protein Information
UniProt AC / UniProt ID | Q92918 / M4K1_HUMAN |
Protein Name | Mitogen-activated protein kinase kinase kinase kinase 1 |
Gene Name | Name: MAP4K1 Synonyms:HPK1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q92918 |
PRO Name | mitogen-activated protein kinase kinase kinase kinase 1 (human) |
Definition | A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human. |
Short Label | hMAP4K1 |
Category | organism-gene |
Q92918 (MAP4K1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y28 | Phosphorylation | score1 | PhosphoSitePlus | |||
K33 | Ubiquitination | score1 | PhosphoSitePlus | |||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
C69 | Methylation | score1 | IEDB | 31844290 | ||
T165 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 15743830, 24362026 | ||
T165 | Phosphorylation | Q92918 (MAP4K1) | score4 | PhosphoSitePlus Signor UniProt | 15743830, 24362026 | |
S171 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 15743830, 24362026 | ||
S171 | Phosphorylation | Q15139 (PRKD1) | score3 | neXtProt PhosphoSitePlus | 15743830 | |
S171 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
T175 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 24362026 | ||
T175 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
Y177 | Phosphorylation | score1 | PhosphoSitePlus | |||
S230 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y232 | Phosphorylation | score1 | Signor | 11278340 | ||
Y232 | Phosphorylation | P00519 (ABL1) | score1 | Signor | 11278340 | |
K257 | Acetylation | score1 | IEDB | 34357683 | ||
S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
K296 | Ubiquitination | score1 | PhosphoSitePlus | |||
S320 | Phosphorylation | score1 | PhosphoSitePlus | |||
S324 | Phosphorylation | score1 | PhosphoSitePlus | |||
S325 | Phosphorylation | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
T349 | Phosphorylation | score1 | PhosphoSitePlus | |||
T355 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 24362026 | ||
T355 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
S366 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15302935 | ||
S368 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15302935 | ||
S374 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17192257 | ||
S376 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 17353368, 22105350, 17192257 | ||
S377 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y381 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor | 11514608, 17192257, 11487585 | ||
Y381 | Phosphorylation | P43405 (SYK) | score3 | phospho.ELM Signor | 11514608 | |
S405 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
S407 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19690332, 17192257 | ||
S413 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19690332, 17192257 | ||
S421 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19369195, 19690332, 17192257 | ||
S430 | Phosphorylation | score1 | PhosphoSitePlus | |||
S436 | Phosphorylation | score1 | PhosphoSitePlus | |||
S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
S446 | Phosphorylation | score1 | PhosphoSitePlus | |||
S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
T451 | Phosphorylation | score1 | PhosphoSitePlus | |||
S454 | Phosphorylation | score1 | PhosphoSitePlus | |||
C494 | Methylation | score1 | IEDB | 31844290 | ||
S586 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19369195, 17192257 | ||
K594 | Ubiquitination | score1 | PhosphoSitePlus | |||
S598 | Phosphorylation | score1 | PhosphoSitePlus | |||
T599 | Phosphorylation | score1 | PhosphoSitePlus | |||
K600 | Ubiquitination | score1 | PhosphoSitePlus | |||
C674 | Methylation | score1 | IEDB | 31844290 | ||
S737 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y232 | Phosphorylation | score1 | HPRD | 11278340 | ||
Y232 | Phosphorylation | P00519 (ABL1) | score1 | HPRD | 11278340 | |
S366 | Phosphorylation | score0 | HPRD | 15302935 | ||
S368 | Phosphorylation | score0 | HPRD | 15302935 | ||
S376 | Phosphorylation | score0 | HPRD | 17192257 | ||
S376 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S377 | Phosphorylation | score0 | HPRD | 17192257 | ||
S377 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
Y381 | Phosphorylation | score1 | HPRD | 11514608 | ||
Y381 | Phosphorylation | P07948 (LYN) | score1 | HPRD | 11514608 | |
Y381 | Phosphorylation | P43405 (SYK) | score1 | HPRD | 11514608 | |
S407 | Phosphorylation | score0 | HPRD | 17192257 | ||
S407 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S421 | Phosphorylation | score0 | HPRD | 17192257 | ||
S421 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S586 | Phosphorylation | score0 | HPRD | 17192257 | ||
S586 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S376 | Phosphorylation | score0 | HPRD | 17192257 | ||
S376 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S377 | Phosphorylation | score0 | HPRD | 17192257 | ||
S377 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
Y381 | Phosphorylation | score0 | HPRD | 17192257 | ||
Y381 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S407 | Phosphorylation | score0 | HPRD | 17192257 | ||
S407 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S421 | Phosphorylation | score0 | HPRD | 17192257 | ||
S421 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
S586 | Phosphorylation | score0 | HPRD | 17192257 | ||
S586 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 |
Q92918 (MAP4K1) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
Q13094 (LCP2) | S376 | score4 | phospho.ELM PhosphoSitePlus Signor | 17353368, 22902619 | |
Q16584 (MAP3K11) | S281 | score3 | HPRD phospho.ELM PhosphoSitePlus Signor | 11053428 | |
Q92918 (MAP4K1) | T165 | score4 | PhosphoSitePlus Signor UniProt | 15743830, 24362026 | |
Q92918 (MAP4K1) | S171 | score2 | UniProt | 24362026 | |
Q92918 (MAP4K1) | T175 | score2 | UniProt | 24362026 | |
Q92918 (MAP4K1) | T355 | score2 | UniProt | 24362026 | |
Q92918-2 (MAP4K1) | S376 | score0 | HPRD | 17192257 | |
Q92918-1 (MAP4K1) | S377 | score0 | HPRD | 17192257 | |
Q92918-2 (MAP4K1) | Y381 | score0 | HPRD | 17192257 | |
Q92918-1 (MAP4K1) | S407 | score0 | HPRD | 17192257 | |
Q92918-1 (MAP4K1) | S421 | score0 | HPRD | 17192257 | |
Q92918-1 (MAP4K1) | S586 | score0 | HPRD | 17192257 | |
Q9BXL7 (CARD11) | S556 | score2 | PhosphoSitePlus | 19706536 | |
Q9BXL7 (CARD11) | S558 | score2 | PhosphoSitePlus | 19706536 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S376 | L376 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |