iPTMnet Report for Q92918 (MAP4K1)
Protein Information
| UniProt AC / UniProt ID | Q92918 / M4K1_HUMAN |
| Protein Name | Mitogen-activated protein kinase kinase kinase kinase 1 |
| Gene Name | Name: MAP4K1 Synonyms:HPK1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q92918 |
| PRO Name | mitogen-activated protein kinase kinase kinase kinase 1 (human) |
| Definition | A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human. |
| Short Label | hMAP4K1 |
| Category | organism-gene |
DAG ViewQ92918 (MAP4K1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y28 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K33 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C69 | Methylation | score1 | IEDB | 31844290 | ||
| T165 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 15743830, 24362026 | ||
| T165 | Phosphorylation | Q92918 (MAP4K1) | score4 | PhosphoSitePlus Signor UniProt | 15743830, 24362026 | |
| S171 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 15743830, 24362026 | ||
| S171 | Phosphorylation | Q15139 (PRKD1) | score3 | neXtProt PhosphoSitePlus | 15743830 | |
| S171 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
| T175 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 24362026 | ||
| T175 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
| Y177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S230 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y232 | Phosphorylation | score1 | Signor | 11278340 | ||
| Y232 | Phosphorylation | P00519 (ABL1) | score1 | Signor | 11278340 | |
| K257 | Acetylation | score1 | IEDB | 34357683 | ||
| S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K296 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S320 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S324 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T349 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T355 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 24362026 | ||
| T355 | Phosphorylation | Q92918 (MAP4K1) | score2 | UniProt | 24362026 | |
| S366 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15302935 | ||
| S368 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15302935 | ||
| S374 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17192257 | ||
| S376 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 17353368, 22105350, 17192257 | ||
| S377 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y381 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor | 11514608, 17192257, 11487585 | ||
| Y381 | Phosphorylation | P43405 (SYK) | score3 | phospho.ELM Signor | 11514608 | |
| S405 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
| S407 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19690332, 17192257 | ||
| S413 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19690332, 17192257 | ||
| S421 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19369195, 19690332, 17192257 | ||
| S430 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S436 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S446 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T451 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S454 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C494 | Methylation | score1 | IEDB | 31844290 | ||
| S586 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 19369195, 17192257 | ||
| K594 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S598 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T599 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K600 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C674 | Methylation | score1 | IEDB | 31844290 | ||
| S737 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y232 | Phosphorylation | score1 | HPRD | 11278340 | ||
| Y232 | Phosphorylation | P00519 (ABL1) | score1 | HPRD | 11278340 | |
| S366 | Phosphorylation | score0 | HPRD | 15302935 | ||
| S368 | Phosphorylation | score0 | HPRD | 15302935 | ||
| S376 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S376 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S377 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S377 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| Y381 | Phosphorylation | score1 | HPRD | 11514608 | ||
| Y381 | Phosphorylation | P07948 (LYN) | score1 | HPRD | 11514608 | |
| Y381 | Phosphorylation | P43405 (SYK) | score1 | HPRD | 11514608 | |
| S407 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S407 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S421 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S421 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S586 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S586 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S376 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S376 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S377 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S377 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| Y381 | Phosphorylation | score0 | HPRD | 17192257 | ||
| Y381 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S407 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S407 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S421 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S421 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 | |
| S586 | Phosphorylation | score0 | HPRD | 17192257 | ||
| S586 | Phosphorylation | Q92918 (MAP4K1) | score0 | HPRD | 17192257 |
Q92918 (MAP4K1) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q13094 (LCP2) | S376 | score4 | phospho.ELM PhosphoSitePlus Signor | 17353368, 22902619 | |
| Q16584 (MAP3K11) | S281 | score3 | HPRD phospho.ELM PhosphoSitePlus Signor | 11053428 | |
| Q92918 (MAP4K1) | T165 | score4 | PhosphoSitePlus Signor UniProt | 15743830, 24362026 | |
| Q92918 (MAP4K1) | S171 | score2 | UniProt | 24362026 | |
| Q92918 (MAP4K1) | T175 | score2 | UniProt | 24362026 | |
| Q92918 (MAP4K1) | T355 | score2 | UniProt | 24362026 | |
| Q92918-2 (MAP4K1) | S376 | score0 | HPRD | 17192257 | |
| Q92918-1 (MAP4K1) | S377 | score0 | HPRD | 17192257 | |
| Q92918-2 (MAP4K1) | Y381 | score0 | HPRD | 17192257 | |
| Q92918-1 (MAP4K1) | S407 | score0 | HPRD | 17192257 | |
| Q92918-1 (MAP4K1) | S421 | score0 | HPRD | 17192257 | |
| Q92918-1 (MAP4K1) | S586 | score0 | HPRD | 17192257 | |
| Q9BXL7 (CARD11) | S556 | score2 | PhosphoSitePlus | 19706536 | |
| Q9BXL7 (CARD11) | S558 | score2 | PhosphoSitePlus | 19706536 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S376 | L376 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
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