Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92918 / M4K1_HUMAN
Protein Name Mitogen-activated protein kinase kinase kinase kinase 1
Gene Name Name: MAP4K1
Synonyms:HPK1;
Organism Homo sapiens (Human)

PRO ID PR:Q92918
DAG View
PRO Name mitogen-activated protein kinase kinase kinase kinase 1 (human)
Definition A mitogen-activated protein kinase kinase kinase kinase 1 that is encoded in the genome of human.
Short Label hMAP4K1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92918 (MAP4K1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y28 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
T165 Phosphorylation Q92918 (MAP4K1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15743830, 24362026
S171 Phosphorylation Q92918 (MAP4K1) , Q15139 (PRKD1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15743830, 24362026
T175 Phosphorylation Q92918 (MAP4K1) PhosphoSitePlus   UniProt 24362026
Y177 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y232 Phosphorylation P00519 (ABL1) Signor 11278340
S258 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
T355 Phosphorylation Q92918 (MAP4K1) PhosphoSitePlus   UniProt 24362026
S366 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S368 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S374 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S376 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17353368, 22105350, 17192257
S377 Phosphorylation PhosphoSitePlus
Y381 Phosphorylation P43405 (SYK) phospho.ELM   PhosphoSitePlus   Signor 11514608, 17192257, 11487585
S405 Phosphorylation PhosphoSitePlus   UniProt 19690332
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 17192257
S413 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 17192257
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 19690332, 17192257
S430 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S586 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 17192257
K594 Ubiquitination PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y232 Phosphorylation P00519 (ABL1) HPRD 11278340
S366 Phosphorylation HPRD 15302935
S368 Phosphorylation HPRD 15302935
S376 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S377 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
Y381 Phosphorylation P43405 (SYK) , P07948 (LYN) HPRD 11514608
S407 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S421 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S586 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
Site PTM Type PTM Enzyme Score Source PMID
S376 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S377 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
Y381 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S407 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S421 Phosphorylation Q92918 (MAP4K1) HPRD 17192257
S586 Phosphorylation Q92918 (MAP4K1) HPRD 17192257


Q92918 (MAP4K1) as PTM Enzyme



Substrate Site Score Source PMID
Q13094 (LCP2) S376 phospho.ELM   PhosphoSitePlus   Signor 17353368, 22902619
Q16584 (MAP3K11) S281 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11053428
Q92918 (MAP4K1) T165 PhosphoSitePlus   Signor   UniProt 15743830, 24362026
Q92918 (MAP4K1) S171 UniProt 24362026
Q92918 (MAP4K1) T175 UniProt 24362026
Q92918 (MAP4K1) T355 UniProt 24362026
Q92918-2 (MAP4K1) S376 HPRD 17192257
Q92918-2 (MAP4K1) S377 HPRD 17192257
Q92918-2 (MAP4K1) Y381 HPRD 17192257
Q92918-1 (MAP4K1) S407 HPRD 17192257
Q92918-1 (MAP4K1) S421 HPRD 17192257
Q92918-1 (MAP4K1) S586 HPRD 17192257
Q9BXL7 (CARD11) S556 PhosphoSitePlus 19706536
Q9BXL7 (CARD11) S558 PhosphoSitePlus 19706536


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y177 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S447 R447 Biomuta DOID:3571 / liver cancer [ icgc ]