Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92743 / HTRA1_HUMAN
Protein Name Serine protease HTRA1 precursor
Gene Name Name: HTRA1
Synonyms:HTRA,PRSS11;
Organism Homo sapiens (Human)

PRO ID PR:Q92743
DAG View
PRO Name serine protease HTRA1 (human)
Definition A serine protease HTRA1 that is encoded in the genome of human.
Short Label hHTRA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92743 (HTRA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K168 Acetylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y238 H238 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T365 M365 Biomuta DOID:1324 / lung cancer [ tcga ]
S456 I456 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]