iPTMnet Report for Q92731 (ESR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q92731 / ESR2_HUMAN
Protein Name Estrogen receptor beta
Gene Name Name: ESR2
Synonyms:ESTRB,NR3A2;
Organism Homo sapiens (Human)

PRO ID PR:Q92731
DAG View
PRO Name estrogen receptor beta (human)
Definition An estrogen receptor beta that is encoded in the genome of human.
Short Label hESR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q92731 (ESR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y36 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 24960160
Y56 Phosphorylation PhosphoSitePlus
S75 Phosphorylation RLIMS-P 22370157
S87 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22370157, 15862947, 19584281
S105 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10230404, 20696772, 15862947, ...22370157
S135 Phosphorylation PhosphoSitePlus
C152 Methylation IEDB 31844290
S165 Phosphorylation phospho.ELM 9528769
S176 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus   RLIMS-P 22930062


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y36 H36 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C152 F152 Biomuta DOID:3571 / liver cancer [ cosmic ]