iPTMnet Report for Q8WZ60 (KLHL6)
Protein Information
| UniProt AC / UniProt ID | Q8WZ60 / KLHL6_HUMAN |
| Protein Name | Kelch-like protein 6 |
| Gene Name | Name: KLHL6 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8WZ60 |
| PRO Name | kelch-like protein 6 (human) |
| Definition | A kelch-like protein 6 that is encoded in the genome of human. |
| Short Label | hKLHL6 |
| Category | organism-gene |
Q8WZ60 (KLHL6) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S55 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T64 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C77 | Methylation | score1 | IEDB | 31844290 | ||
| K108 | Acetylation | score1 | PhosphoSitePlus | |||
| K116 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y297 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S300 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C339 | Methylation | score1 | IEDB | 31844290 | ||
| K352 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K385 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C447 | Methylation | score1 | IEDB | 31844290 | ||
| K485 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K495 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K499 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K507 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C508 | Methylation | score1 | IEDB | 31844290 | ||
| C539 | Methylation | score1 | IEDB | 31844290 | ||
| C556 | Methylation | score1 | IEDB | 31844290 | ||
| S597 | Phosphorylation | score1 | IEDB | 35494241 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S55 | C55 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| T64 | A64 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| T64 | S64 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| T64 | I64 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| C77 | Y77 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| C77 | F77 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| C77 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K116 | E116 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| C339 | S339 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] | |
| C339 | Y339 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| C339 | * | Biomuta | [ cosmic ] | |
| K485 | N485 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] | |
| K485 | T485 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| C556 | S556 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View