iPTMnet Report for Q8WWH5 (TRUB1)
Protein Information
UniProt AC / UniProt ID | Q8WWH5 / TRUB1_HUMAN |
Protein Name | Pseudouridylate synthase TRUB1 |
Gene Name | Name: TRUB1 Synonyms:PUS4; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q8WWH5 |
PRO Name | pseudouridylate synthase TRUB1 (human) |
Definition | A pseudouridylate synthase TRUB1 that is encoded in the genome of human. |
Short Label | hTRUB1 |
Category | organism-gene |
Q8WWH5 (TRUB1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330, 22223895, 20068231 | ||
S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
S10 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 23186163, 20068231 | ||
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
T24 | Phosphorylation | score0 | HPRD | 20068231 | ||
T27 | Phosphorylation | score1 | PhosphoSitePlus | |||
T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
S36 | Phosphorylation | score1 | PhosphoSitePlus | |||
K58 | Ubiquitination | score1 | PhosphoSitePlus | |||
R88 | Methylation | score1 | PhosphoSitePlus | |||
K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
K106 | Ubiquitination | score1 | PhosphoSitePlus | |||
T119 | Phosphorylation | score1 | PhosphoSitePlus | |||
S122 | Phosphorylation | score1 | PhosphoSitePlus | |||
S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
S144 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
S146 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y149 | Phosphorylation | score1 | PhosphoSitePlus | |||
K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y174 | Phosphorylation | score1 | PhosphoSitePlus | |||
K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
S201 | Phosphorylation | score1 | PhosphoSitePlus | |||
K204 | Acetylation | score1 | PhosphoSitePlus | |||
K204 | Ubiquitination | score1 | PhosphoSitePlus | |||
K205 | Acetylation | score1 | PhosphoSitePlus | |||
K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
K321 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y333 | Phosphorylation | score1 | PhosphoSitePlus | |||
K340 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | V2 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S4 | C4 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S11 | L11 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S19 | Y19 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S19 | F19 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T34 | P34 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
K90 | T90 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S134 | G134 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
S144 | L144 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S146 | F146 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K157 | E157 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
K176 | T176 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
K294 | T294 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |