iPTMnet Report for Q8WWH5 (TRUB1)
Protein Information
| UniProt AC / UniProt ID | Q8WWH5 / TRUB1_HUMAN |
| Protein Name | Pseudouridylate synthase TRUB1 |
| Gene Name | Name: TRUB1 Synonyms:PUS4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q8WWH5 |
| PRO Name | pseudouridylate synthase TRUB1 (human) |
| Definition | A pseudouridylate synthase TRUB1 that is encoded in the genome of human. |
| Short Label | hTRUB1 |
| Category | organism-gene |
Q8WWH5 (TRUB1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 19413330, 22223895, 20068231 | ||
| S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S10 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S11 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T24 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T34 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S36 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K58 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R88 | Methylation | score1 | PhosphoSitePlus | |||
| K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K106 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T119 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S144 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
| S146 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447, ... | ||
| K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y149 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y174 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K176 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S201 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K204 | Acetylation | score1 | PhosphoSitePlus | |||
| K204 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K205 | Acetylation | score1 | PhosphoSitePlus | |||
| K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K264 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K321 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y333 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K340 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | V2 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S4 | C4 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S11 | L11 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S19 | Y19 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S19 | F19 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T34 | P34 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
| K90 | T90 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S134 | G134 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S144 | L144 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S146 | F146 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K157 | E157 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| K176 | T176 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
| K294 | T294 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] |
DAG View