iPTMnet Report for Q8WVD3 (RNF138)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8WVD3 / RN138_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF138
Gene Name Name: RNF138
Synonyms:NARF;ORFNames:HSD-4,HSD4;
Organism Homo sapiens (Human)

PRO ID PR:Q8WVD3
DAG View
PRO Name E3 ubiquitin-protein ligase RNF138 (human)
Definition An E3 ubiquitin-protein ligase RNF138 that is encoded in the genome of human.
Short Label hRNF138
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8WVD3 (RNF138) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
K26 Ubiquitination PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
R80 Methylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S127 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus   UniProt 23186163
T144 Phosphorylation PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T168 Phosphorylation IEDB 35494241
Site PTM Type PTM Enzyme Score Source PMID
S124 Phosphorylation HPRD 17525332, 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y108 H108 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S139 F139 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T142 A142 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y145 C145 Biomuta DOID:9256 / colorectal cancer [ cosmic ]