iPTMnet Report for Q8TEJ3 (SH3RF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TEJ3 / SH3R3_HUMAN
Protein Name E3 ubiquitin-protein ligase SH3RF3
Gene Name Name: SH3RF3
Synonyms:POSH2;
Organism Homo sapiens (Human)

PRO ID PR:Q8TEJ3
DAG View
PRO Name E3 ubiquitin-protein ligase SH3RF3 (human)
Definition An E3 ubiquitin-protein ligase SH3RF3 that is encoded in the genome of human.
Short Label hSH3RF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TEJ3 (SH3RF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
T383 Phosphorylation HPRD   PhosphoSitePlus 18767875
S400 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S412 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
Y469 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
S542 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T549 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
T732 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S797 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S881 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T67 M67 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S381 F381 Biomuta DOID:4159 / skin cancer [ cosmic ]
S412 R412 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S437 F437 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S437 Y437 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S438 L438 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T458 M458 Biomuta DOID:1324 / lung cancer [ cosmic ]
S797 F797 Biomuta DOID:4159 / skin cancer [ cosmic ]