iPTMnet Report for Q8TDN4 (CABLES1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8TDN4 / CABL1_HUMAN
Protein Name CDK5 and ABL1 enzyme substrate 1
Gene Name Name: CABLES1
Synonyms:CABLES;
Organism Homo sapiens (Human)

PRO ID PR:Q8TDN4
DAG View
PRO Name CDK5 and ABL1 enzyme substrate 1 (human)
Definition A CDK5 and ABL1 enzyme substrate 1 that is encoded in the genome of human.
Short Label hCABLES1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8TDN4 (CABLES1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R107 Methylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S168 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...19369195
S242 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S290 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus   Signor 11733001
S313 Phosphorylation Q00526 (CDK3) PhosphoSitePlus   Signor 11733001
T333 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
T415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 18691976, ...18220336
S418 Phosphorylation PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S22 Phosphorylation HPRD 18691976
S25 Phosphorylation HPRD 18691976
S26 Phosphorylation HPRD 18691976
T44 Phosphorylation HPRD 18691976
S46 Phosphorylation HPRD 18691976
S48 Phosphorylation HPRD 11733001, 18691976
S48 Phosphorylation P24864 (CCNE1) HPRD 11733001, 18691976
S48 Phosphorylation Q00526 (CDK3) HPRD 11733001, 18691976
S108 Phosphorylation HPRD 18691976
S113 Phosphorylation HPRD 18691976
T150 Phosphorylation HPRD 18691976, 18669648
S153 Phosphorylation HPRD 18691976
S169 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 F25 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S26 F26 Biomuta DOID:4159 / skin cancer [ cosmic ]
S46 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S48 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S108 P108 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S290 F290 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S291 F291 Biomuta DOID:4159 / skin cancer [ cosmic ]
S311 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S313 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S373 P373 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S432 C432 Biomuta DOID:1319 / brain cancer [ cosmic ]