iPTMnet Report Q8TBK2 SETD6

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q8TBK2 / SETD6_HUMAN
Protein Name	N-lysine methyltransferase SETD6
Gene Name	Name: SETD6
Organism	Homo sapiens (Human)

PRO ID	PR:Q8TBK2 DAG View
PRO Name	N-lysine methyltransferase SETD6 (human)
Definition	An N-lysine methyltransferase SETD6 that is encoded in the genome of human.
Short Label	hSETD6
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q8TBK2 (SETD6) as Substrate

Q8TBK2

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K39	Methylation	Q8TBK2 (SETD6)	score2	UniProt	30189201
	K39	Ubiquitination		score1	PhosphoSitePlus
	S118	Phosphorylation		score1	PhosphoSitePlus
	S120	Phosphorylation		score1	PhosphoSitePlus
	S138	Phosphorylation		score1	PhosphoSitePlus
	K179	Methylation	Q8TBK2 (SETD6)	score2	UniProt	30189201
	K327	Ubiquitination		score1	PhosphoSitePlus
	K372	Methylation	Q8TBK2 (SETD6)	score2	UniProt	30189201
	K385	Ubiquitination		score1	PhosphoSitePlus
	K394	Ubiquitination		score1	PhosphoSitePlus
	K441	Ubiquitination		score1	PhosphoSitePlus

Q8TBK2 (SETD6) as PTM Enzyme

Protein as Methylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q8TBK2 (SETD6)	K39	score2	UniProt	30189201
	Q8TBK2 (SETD6)	K179	score2	UniProt	30189201
	Q8TBK2 (SETD6)	K372	score2	UniProt	30189201

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K179	N179	Biomuta		DOID:9253 / gastrointestinal stromal tumor [ cosmic ]