iPTMnet Report for Q8NF91 (SYNE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NF91 / SYNE1_HUMAN
Protein Name Nesprin-1
Gene Name Name: SYNE1
Synonyms:C6orf98,KIAA0796,KIAA1262,KIAA1756,MYNE1;
Organism Homo sapiens (Human)

PRO ID PR:Q8NF91
DAG View
PRO Name nesprin-1 (human)
Definition A nesprin-1 that is encoded in the genome of human.
Short Label hSYNE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NF91 (SYNE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T34 O-Glycosylation GlyGen 30379171
S165 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K643 Acetylation PhosphoSitePlus
Y713 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
T725 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
S1286 O-Glycosylation GlyGen 30379171, 36240223, 29351928
T1320 Phosphorylation PhosphoSitePlus
T1338 Phosphorylation PhosphoSitePlus
Y1355 Phosphorylation PhosphoSitePlus
K1383 Methylation PhosphoSitePlus
S1679 Phosphorylation PhosphoSitePlus
S1686 Phosphorylation PhosphoSitePlus
S1728 Phosphorylation PhosphoSitePlus
K1729 Ubiquitination PhosphoSitePlus
S1832 Phosphorylation PhosphoSitePlus
K1899 Ubiquitination PhosphoSitePlus
T1951 O-Glycosylation GlyGen 30379171, 36240223, 29351928
K1987 Ubiquitination PhosphoSitePlus
S1993 Phosphorylation PhosphoSitePlus
K2003 Methylation PhosphoSitePlus
Y2091 Phosphorylation PhosphoSitePlus
T2111 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
Y2370 Phosphorylation PhosphoSitePlus
S2372 Phosphorylation PhosphoSitePlus
S2377 Phosphorylation PhosphoSitePlus
R2865 Methylation PhosphoSitePlus
S2873 Phosphorylation PhosphoSitePlus
S2874 Phosphorylation PhosphoSitePlus
T2876 Phosphorylation PhosphoSitePlus
K3011 Ubiquitination PhosphoSitePlus
K3020 Ubiquitination PhosphoSitePlus
S3037 Phosphorylation PhosphoSitePlus
R3068 Methylation PhosphoSitePlus
K3176 Acetylation PhosphoSitePlus
K3191 Acetylation PhosphoSitePlus
K3191 Ubiquitination PhosphoSitePlus
K3209 Ubiquitination PhosphoSitePlus
S3382 O-Glycosylation GlyGen 30379171, 36240223, 29351928
T3426 Phosphorylation PhosphoSitePlus
T3427 Phosphorylation PhosphoSitePlus
K3481 Acetylation PhosphoSitePlus
S3487 Phosphorylation PhosphoSitePlus
T3616 Phosphorylation PhosphoSitePlus
S3622 Phosphorylation PhosphoSitePlus
S3629 Phosphorylation PhosphoSitePlus
T3633 Phosphorylation PhosphoSitePlus
T3680 Phosphorylation PhosphoSitePlus
T3683 Phosphorylation PhosphoSitePlus
S3684 Phosphorylation PhosphoSitePlus
E3758 Methylation IEDB 32357974
Y3777 Phosphorylation PhosphoSitePlus
T3891 Phosphorylation PhosphoSitePlus
Y3903 Phosphorylation PhosphoSitePlus
T4088 Phosphorylation PhosphoSitePlus
Y4089 Phosphorylation PhosphoSitePlus
S4095 Phosphorylation PhosphoSitePlus
S4100 Phosphorylation PhosphoSitePlus
S4103 Phosphorylation PhosphoSitePlus
S4173 Phosphorylation PhosphoSitePlus
T4191 Phosphorylation PhosphoSitePlus
K4333 Methylation PhosphoSitePlus
S4403 Phosphorylation PhosphoSitePlus
K4736 Ubiquitination PhosphoSitePlus
S4828 Phosphorylation PhosphoSitePlus
T4836 O-Glycosylation GlyGen 30379171, 36240223, 29351928
S4937 Phosphorylation PhosphoSitePlus
S4945 Phosphorylation PhosphoSitePlus
T5132 Phosphorylation IEDB 32387766
T5193 Phosphorylation PhosphoSitePlus
K5495 Acetylation PhosphoSitePlus
K5789 Ubiquitination PhosphoSitePlus
Y5791 Phosphorylation IEDB   PhosphoSitePlus 35494241
S5881 Phosphorylation PhosphoSitePlus
S5883 Phosphorylation PhosphoSitePlus
Y5925 Phosphorylation PhosphoSitePlus
K5936 Ubiquitination PhosphoSitePlus
S5943 Phosphorylation PhosphoSitePlus
K5948 Ubiquitination PhosphoSitePlus
K5954 Ubiquitination PhosphoSitePlus
T5957 Phosphorylation PhosphoSitePlus
Y5959 Phosphorylation PhosphoSitePlus
K5967 Ubiquitination PhosphoSitePlus
Y5968 Phosphorylation PhosphoSitePlus
S5989 Phosphorylation PhosphoSitePlus
K6168 Ubiquitination PhosphoSitePlus
S6175 Phosphorylation PhosphoSitePlus
K6186 Ubiquitination PhosphoSitePlus
S6230 Phosphorylation PhosphoSitePlus
S6301 Phosphorylation PhosphoSitePlus
S6334 Phosphorylation PhosphoSitePlus
S6376 Phosphorylation PhosphoSitePlus
K6437 Acetylation PhosphoSitePlus
S6466 Phosphorylation IEDB 35494241
S6499 Phosphorylation PhosphoSitePlus
Y6505 Phosphorylation PhosphoSitePlus
K6544 Ubiquitination PhosphoSitePlus
S6618 Phosphorylation PhosphoSitePlus
T6660 Phosphorylation PhosphoSitePlus
T6664 Phosphorylation PhosphoSitePlus
S6710 O-Glycosylation GlyGen 30379171, 36240223, 29351928
S6711 O-Glycosylation GlyGen 30379171, 36240223, 29351928
S6714 O-Glycosylation GlyGen 30379171, 36240223, 29351928
Y6747 Phosphorylation PhosphoSitePlus
S6882 Phosphorylation PhosphoSitePlus
T6893 Phosphorylation PhosphoSitePlus
S6912 Phosphorylation PhosphoSitePlus
Y6943 Phosphorylation PhosphoSitePlus
Y6953 Phosphorylation PhosphoSitePlus
Y7151 Phosphorylation PhosphoSitePlus
S7154 Phosphorylation PhosphoSitePlus
T7270 O-Glycosylation GlyGen 30379171, 36240223, 29351928
S7405 Phosphorylation PhosphoSitePlus
Y7584 Phosphorylation PhosphoSitePlus
S7847 Phosphorylation PhosphoSitePlus
C7966 Methylation IEDB 33981976
Y8032 Phosphorylation PhosphoSitePlus
T8033 Phosphorylation PhosphoSitePlus
S8223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S8232 Phosphorylation PhosphoSitePlus
S8236 Phosphorylation PhosphoSitePlus
S8250 Phosphorylation PhosphoSitePlus
S8270 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T8274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8305 Phosphorylation PhosphoSitePlus
S8345 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T8352 Phosphorylation PhosphoSitePlus
S8358 Phosphorylation PhosphoSitePlus
T8360 Phosphorylation PhosphoSitePlus   UniProt 24275569
T8362 Phosphorylation PhosphoSitePlus
T8368 Phosphorylation PhosphoSitePlus
Y8373 Phosphorylation PhosphoSitePlus
K8393 Acetylation PhosphoSitePlus
K8395 Acetylation PhosphoSitePlus
S8400 Phosphorylation PhosphoSitePlus
K8431 Acetylation PhosphoSitePlus
S8472 Phosphorylation PhosphoSitePlus
K8486 Acetylation PhosphoSitePlus
K8490 Acetylation PhosphoSitePlus
C8535 Methylation IEDB 31844290
K8599 Ubiquitination PhosphoSitePlus
S8685 Phosphorylation PhosphoSitePlus
S8704 Phosphorylation PhosphoSitePlus
S8706 Phosphorylation PhosphoSitePlus
S8713 Phosphorylation PhosphoSitePlus
S8714 Phosphorylation PhosphoSitePlus
S8717 Phosphorylation PhosphoSitePlus
S8724 Phosphorylation PhosphoSitePlus
S8726 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S494 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S172 Phosphorylation HPRD 20058876
S1334 Phosphorylation HPRD 17081983
S1735 Phosphorylation HPRD 19664994
S2384 Phosphorylation HPRD 20068231
T2985 Phosphorylation HPRD 20068231
S3581 Phosphorylation HPRD 19413330
T3876 Phosphorylation HPRD 17924679
T4440 Phosphorylation HPRD 20068231
Y4747 Phosphorylation HPRD 17081983
S4749 Phosphorylation HPRD 17081983
Y5897 Phosphorylation HPRD 20068231
S5905 Phosphorylation HPRD 20068231
T5906 Phosphorylation HPRD 20068231
S7026 Phosphorylation HPRD 20068231
S7031 Phosphorylation HPRD 20068231
T7032 Phosphorylation HPRD 20068231
Y7961 Phosphorylation HPRD 19651622, 20068231
T7962 Phosphorylation HPRD 19651622, 20068231
S8152 Phosphorylation HPRD 17081983
S8199 Phosphorylation HPRD 17081983
T8203 Phosphorylation HPRD 17081983
S8206 Phosphorylation HPRD 19651622, 17081983
S8209 Phosphorylation HPRD 19651622, 17081983
S8261 Phosphorylation PhosphoSitePlus
S8277 Phosphorylation PhosphoSitePlus
S8297 Phosphorylation HPRD 17081983, 20068231
S8310 Phosphorylation HPRD 19651622
T8312 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S165 N165 Biomuta DOID:4159 / skin cancer [ cosmic ]
S165 R165 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S379 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T393 S393 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S525 Y525 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S525 F525 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K643 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K643 T643 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y713 C713 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]
T714 K714 Biomuta DOID:1319 / brain cancer [ cosmic ]
T725 A725 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T774 S774 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1320 K1320 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T1320 I1320 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1686 Y1686 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1686 F1686 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1728 F1728 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1832 Y1832 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1899 E1899 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1899 N1899 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T1951 S1951 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1951 A1951 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T2111 A2111 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2213 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2377 G2377 Biomuta DOID:263 / kidney cancer [ cosmic ]
R3068 I3068 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K3176 N3176 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K3191 E3191 Biomuta DOID:1319 / brain cancer [ cosmic ]
S3382 N3382 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T3427 M3427 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K3481 N3481 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S4095 F4095 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1319 / brain cancer [ cosmic ]
S4103 L4103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S4173 L4173 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T4191 I4191 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K4333 Q4333 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S4403 L4403 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S4937 N4937 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S4937 R4937 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
T5132 S5132 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K5495 T5495 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K5789 N5789 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S5989 C5989 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K6186 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S6376 I6376 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S6466 C6466 Biomuta DOID:1324 / lung cancer [ cosmic ]
S6466 F6466 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S6499 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S6882 L6882 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S7154 F7154 Biomuta DOID:363 / uterine cancer [ cosmic ]
S7154 Y7154 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S7847 I7847 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
C7966 Y7966 Biomuta DOID:4159 / skin cancer [ cosmic ]
S8232 F8232 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S8236 L8236 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S8270 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S8277 N8277 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S8280 F8280 Biomuta DOID:4159 / skin cancer [ cosmic ]
T8362 M8362 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
K8395 N8395 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S8400 I8400 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
K8490 N8490 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S8685 N8685 Biomuta DOID:4159 / skin cancer [ cosmic ]
S8685 R8685 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S8714 G8714 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S8724 F8724 Biomuta DOID:4159 / skin cancer [ cosmic ]
S8726 F8726 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]