Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8NF91 / SYNE1_HUMAN
Protein Name Nesprin-1
Gene Name Name: SYNE1
Synonyms:C6orf98,KIAA0796,KIAA1262,KIAA1756,MYNE1;
Organism Homo sapiens (Human)

PRO ID PR:Q8NF91
DAG View
PRO Name nesprin-1 (human)
Definition A nesprin-1 that is encoded in the genome of human.
Short Label hSYNE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8NF91 (SYNE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
Y530 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
T621 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K643 Acetylation PhosphoSitePlus
Y713 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
T725 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
T1320 Phosphorylation PhosphoSitePlus
T1338 Phosphorylation PhosphoSitePlus
Y1355 Phosphorylation PhosphoSitePlus
K1383 Methylation PhosphoSitePlus
S1679 Phosphorylation PhosphoSitePlus
S1686 Phosphorylation PhosphoSitePlus
S1728 Phosphorylation PhosphoSitePlus
K1729 Ubiquitination PhosphoSitePlus
S1832 Phosphorylation PhosphoSitePlus
K1899 Ubiquitination PhosphoSitePlus
K1987 Ubiquitination PhosphoSitePlus
S1993 Phosphorylation PhosphoSitePlus
K2003 Methylation PhosphoSitePlus
Y2091 Phosphorylation PhosphoSitePlus
T2111 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
Y2370 Phosphorylation PhosphoSitePlus
S2372 Phosphorylation PhosphoSitePlus
S2377 Phosphorylation PhosphoSitePlus
R2865 Methylation PhosphoSitePlus
S2873 Phosphorylation PhosphoSitePlus
S2874 Phosphorylation PhosphoSitePlus
T2876 Phosphorylation PhosphoSitePlus
K3011 Ubiquitination PhosphoSitePlus
K3020 Ubiquitination PhosphoSitePlus
S3037 Phosphorylation PhosphoSitePlus
R3068 Methylation PhosphoSitePlus
K3176 Acetylation PhosphoSitePlus
K3191 Acetylation PhosphoSitePlus
K3191 Ubiquitination PhosphoSitePlus
K3209 Ubiquitination PhosphoSitePlus
T3426 Phosphorylation PhosphoSitePlus
T3427 Phosphorylation PhosphoSitePlus
K3481 Acetylation PhosphoSitePlus
S3487 Phosphorylation PhosphoSitePlus
T3616 Phosphorylation PhosphoSitePlus
S3622 Phosphorylation PhosphoSitePlus
S3629 Phosphorylation PhosphoSitePlus
T3633 Phosphorylation PhosphoSitePlus
T3680 Phosphorylation PhosphoSitePlus
T3683 Phosphorylation PhosphoSitePlus
S3684 Phosphorylation PhosphoSitePlus
Y3777 Phosphorylation PhosphoSitePlus
T3891 Phosphorylation PhosphoSitePlus
Y3903 Phosphorylation PhosphoSitePlus
T4088 Phosphorylation PhosphoSitePlus
Y4089 Phosphorylation PhosphoSitePlus
S4095 Phosphorylation PhosphoSitePlus
S4100 Phosphorylation PhosphoSitePlus
S4103 Phosphorylation PhosphoSitePlus
S4173 Phosphorylation PhosphoSitePlus
T4191 Phosphorylation PhosphoSitePlus
K4333 Methylation PhosphoSitePlus
S4403 Phosphorylation PhosphoSitePlus
K4736 Ubiquitination PhosphoSitePlus
S4828 Phosphorylation PhosphoSitePlus
S4937 Phosphorylation PhosphoSitePlus
S4945 Phosphorylation PhosphoSitePlus
T5193 Phosphorylation PhosphoSitePlus
K5495 Acetylation PhosphoSitePlus
K5789 Ubiquitination PhosphoSitePlus
Y5791 Phosphorylation PhosphoSitePlus
S5881 Phosphorylation PhosphoSitePlus
S5883 Phosphorylation PhosphoSitePlus
Y5925 Phosphorylation PhosphoSitePlus
K5936 Ubiquitination PhosphoSitePlus
S5943 Phosphorylation PhosphoSitePlus
K5948 Ubiquitination PhosphoSitePlus
K5954 Ubiquitination PhosphoSitePlus
T5957 Phosphorylation PhosphoSitePlus
Y5959 Phosphorylation PhosphoSitePlus
K5967 Ubiquitination PhosphoSitePlus
Y5968 Phosphorylation PhosphoSitePlus
S5989 Phosphorylation PhosphoSitePlus
K6168 Ubiquitination PhosphoSitePlus
S6175 Phosphorylation PhosphoSitePlus
K6186 Ubiquitination PhosphoSitePlus
S6230 Phosphorylation PhosphoSitePlus
S6301 Phosphorylation PhosphoSitePlus
S6334 Phosphorylation PhosphoSitePlus
S6376 Phosphorylation PhosphoSitePlus
K6437 Acetylation PhosphoSitePlus
S6499 Phosphorylation PhosphoSitePlus
Y6505 Phosphorylation PhosphoSitePlus
K6544 Ubiquitination PhosphoSitePlus
S6618 Phosphorylation PhosphoSitePlus
T6660 Phosphorylation PhosphoSitePlus
T6664 Phosphorylation PhosphoSitePlus
Y6747 Phosphorylation PhosphoSitePlus
S6882 Phosphorylation PhosphoSitePlus
T6893 Phosphorylation PhosphoSitePlus
S6912 Phosphorylation PhosphoSitePlus
Y6943 Phosphorylation PhosphoSitePlus
Y6953 Phosphorylation PhosphoSitePlus
Y7151 Phosphorylation PhosphoSitePlus
S7154 Phosphorylation PhosphoSitePlus
S7405 Phosphorylation PhosphoSitePlus
Y7584 Phosphorylation PhosphoSitePlus
S7847 Phosphorylation PhosphoSitePlus
T7962 Phosphorylation HPRD 19651622, 20068231
Y8032 Phosphorylation PhosphoSitePlus
T8033 Phosphorylation PhosphoSitePlus
S8223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
S8232 Phosphorylation PhosphoSitePlus
S8236 Phosphorylation PhosphoSitePlus
S8250 Phosphorylation PhosphoSitePlus
S8270 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T8274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8277 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8280 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
S8297 Phosphorylation HPRD 17081983, 20068231
S8305 Phosphorylation PhosphoSitePlus
S8345 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T8352 Phosphorylation PhosphoSitePlus
S8358 Phosphorylation PhosphoSitePlus
T8360 Phosphorylation PhosphoSitePlus   UniProt 24275569
T8362 Phosphorylation PhosphoSitePlus
T8368 Phosphorylation PhosphoSitePlus
Y8373 Phosphorylation PhosphoSitePlus
K8393 Acetylation PhosphoSitePlus
K8395 Acetylation PhosphoSitePlus
S8400 Phosphorylation PhosphoSitePlus
K8431 Acetylation PhosphoSitePlus
S8472 Phosphorylation PhosphoSitePlus
K8486 Acetylation PhosphoSitePlus
K8490 Acetylation PhosphoSitePlus
K8599 Ubiquitination PhosphoSitePlus
S8685 Phosphorylation PhosphoSitePlus
S8704 Phosphorylation PhosphoSitePlus
S8706 Phosphorylation PhosphoSitePlus
S8713 Phosphorylation PhosphoSitePlus
S8714 Phosphorylation PhosphoSitePlus
S8717 Phosphorylation PhosphoSitePlus
S8724 Phosphorylation PhosphoSitePlus
S8726 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S494 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S8261 Phosphorylation PhosphoSitePlus
S8277 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S379 * Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S525 Y525 Biomuta DOID:363 / uterine cancer [ tcga ]
S525 F525 Biomuta DOID:363 / uterine cancer [ tcga ]
K643 * Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
Y713 C713 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
T774 S774 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S790 * Biomuta DOID:3571 / liver cancer [ icgc ]
T1320 K1320 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
T1320 I1320 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1686 Y1686 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1728 F1728 Biomuta DOID:1909 / melanoma [ tcga ] DOID:263 / kidney cancer [ tcga ]
K1729 R1729 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K1899 N1899 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T2111 A2111 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2377 G2377 Biomuta DOID:263 / kidney cancer [ cosmic ]
S2873 * Biomuta DOID:9256 / colorectal cancer [ icgc ]
R3068 I3068 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T3427 M3427 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y3777 * Biomuta DOID:363 / uterine cancer [ tcga ]
Y3903 C3903 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S4095 F4095 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3070 / malignant glioma [ cosmic ]
S4103 L4103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T4191 I4191 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K4333 Q4333 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S4403 L4403 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic, icgc, tcga ]
S4937 N4937 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S4937 R4937 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
K5789 N5789 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K5954 N5954 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y5968 * Biomuta DOID:1612 / breast cancer [ icgc ]
S5989 R5989 Biomuta DOID:3571 / liver cancer [ icgc ]
S5989 C5989 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K6186 * Biomuta DOID:1324 / lung cancer [ tcga ]
S6334 F6334 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S6376 I6376 Biomuta DOID:363 / uterine cancer [ tcga ]
Y6505 C6505 Biomuta DOID:10534 / stomach cancer [ icgc ]
T6660 N6660 Biomuta DOID:3571 / liver cancer [ icgc ]
S6882 L6882 Biomuta DOID:363 / uterine cancer [ tcga ]
S7154 Y7154 Biomuta DOID:1909 / melanoma [ tcga ]
S7847 I7847 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T8033 A8033 Biomuta DOID:10534 / stomach cancer [ icgc ]
S8232 F8232 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S8236 L8236 Biomuta DOID:1909 / melanoma [ cosmic ]
S8270 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S8277 N8277 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S8297 F8297 Biomuta DOID:363 / uterine cancer [ tcga ]
T8362 M8362 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ cosmic ] DOID:0070003 / blastoma [ cosmic ]
T8368 N8368 Biomuta DOID:3571 / liver cancer [ icgc ]
K8395 N8395 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S8400 I8400 Biomuta DOID:10534 / stomach cancer [ tcga ]
S8713 R8713 Biomuta DOID:3571 / liver cancer [ icgc ]
S8714 G8714 Biomuta DOID:363 / uterine cancer [ tcga ]
S8726 F8726 Biomuta DOID:1909 / melanoma [ icgc, tcga ]