Protein Information

Cytoscape View


UniProt AC / UniProt ID Q8N1K5 / THMS1_HUMAN
Protein Name Protein THEMIS
Gene Name Name: THEMIS
Synonyms:C6orf190,C6orf207;
Organism Homo sapiens (Human)

PRO ID PR:Q8N1K5
DAG View
PRO Name protein THEMIS (human)
Definition A protein THEMIS that is encoded in the genome of human.
Short Label hTHEMIS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q8N1K5 (THEMIS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K92 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
Y429 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
Y540 Phosphorylation P06239 (LCK) , P43403 (ZAP70) PhosphoSitePlus 23460737
Y541 Phosphorylation P06239 (LCK) , P43403 (ZAP70) PhosphoSitePlus 23460737
K567 Ubiquitination PhosphoSitePlus
S584 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 15144186
K595 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K586 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P29350 (PTPN6) Y564 Q8N1K5 (THEMIS) unknown eFIP 25535246


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S168 P168 Biomuta DOID:363 / uterine cancer [ tcga ]
K208 T208 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K208 N208 Biomuta DOID:363 / uterine cancer [ tcga ]
Y220 F220 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K359 N359 Biomuta DOID:363 / uterine cancer [ tcga ]
K379 M379 Biomuta DOID:3070 / malignant glioma [ tcga ]
K406 Q406 Biomuta DOID:1909 / melanoma [ cosmic ]
K415 Q415 Biomuta DOID:363 / uterine cancer [ tcga ]
S584 F584 Biomuta DOID:363 / uterine cancer [ tcga ]