Protein Information

Cytoscape View

UniProt AC / UniProt ID Q8IZY2 / ABCA7_HUMAN
Protein Name Phospholipid-transporting ATPase ABCA7
Gene Name Name: ABCA7
Organism Homo sapiens (Human)

DAG View
PRO Name phospholipid-transporting ATPase ABCA7 (human)
Definition A phospholipid-transporting ATPase ABCA7 that is encoded in the genome of human.
Short Label hABCA7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q8IZY2 (ABCA7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N96 N-Glycosylation GlyGen 24190977
N98 N-Glycosylation GlyGen 24190977
K127 Ubiquitination PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
N312 N-Glycosylation GlyGen 24190977
N340 N-Glycosylation GlyGen 24190977
K411 Ubiquitination PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
T555 O-Glycosylation GlyGen 29351928
K932 Ubiquitination PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus
N1335 N-Glycosylation GlyGen 24190977
T1405 Phosphorylation PhosphoSitePlus
N1518 N-Glycosylation GlyGen 29741879, 24190977
T1748 Phosphorylation PhosphoSitePlus
T1844 Phosphorylation PhosphoSitePlus
S2133 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N98 S98 Biomuta DOID:1909 / melanoma [ cosmic ]
S147 F147 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
S182 N182 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S182 G182 Biomuta DOID:4362 / cervical cancer [ tcga ]
N340 D340 Biomuta DOID:11934 / head and neck cancer [ tcga ]
N340 I340 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K411 N411 Biomuta DOID:3070 / malignant glioma [ icgc ]
K932 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]