iPTMnet Report for Q86X27 (RALGPS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86X27 / RGPS2_HUMAN
Protein Name Ras-specific guanine nucleotide-releasing factor RalGPS2
Gene Name Name: RALGPS2
Organism Homo sapiens (Human)

PRO ID PR:Q86X27
DAG View
PRO Name Ras-specific guanine nucleotide-releasing factor RalGPS2 (human)
Definition A Ras-specific guanine nucleotide-releasing factor RalGPS2 that is encoded in the genome of human.
Short Label hRALGPS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86X27 (RALGPS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S311 Phosphorylation PhosphoSitePlus   UniProt 18669648
S315 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S329 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...24275569
S343 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y346 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
K358 Methylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S374 Phosphorylation PhosphoSitePlus   UniProt 23186163
S382 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
S422 O-Glycosylation GlyGen 30459171
S422 Phosphorylation PhosphoSitePlus   UniProt 23186163
T477 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
T512 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y124 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 19413330
S296 Phosphorylation HPRD 19664994
S308 Phosphorylation HPRD 19413330, 18669648, 19664994
S311 Phosphorylation HPRD 18669648
T326 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S329 Phosphorylation HPRD 19413330, 19664994, 19651622, ...18669648, 20166139, 20068231
S343 Phosphorylation HPRD 17081983
T361 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S296 F296 Biomuta DOID:4159 / skin cancer [ cosmic ]
S308 C308 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S329 F329 Biomuta DOID:4159 / skin cancer [ cosmic ]
S359 I359 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T361 P361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T361 M361 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S374 R374 Biomuta DOID:1324 / lung cancer [ cosmic ]
S422 C422 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]