iPTMnet Report for Q86SG6 (NEK8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86SG6 / NEK8_HUMAN
Protein Name Serine/threonine-protein kinase Nek8
Gene Name Name: NEK8
Synonyms:JCK,NEK12A;
Organism Homo sapiens (Human)

PRO ID PR:Q86SG6
DAG View
PRO Name serine/threonine-protein kinase Nek8 (human)
Definition A serine/threonine-protein kinase Nek8 that is encoded in the genome of human.
Short Label hNEK8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86SG6 (NEK8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T131 Phosphorylation HPRD   PhosphoSitePlus 18491316
K138 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
T162 Phosphorylation Q86SG6 (NEK8) HPRD   PhosphoSitePlus   RLIMS-P 22106379, 11864968
C450 Methylation IEDB 31844290
K639 Ubiquitination PhosphoSitePlus


Q86SG6 (NEK8) as PTM Enzyme



Substrate Site Score Source PMID
Q86SG6 (NEK8) T162 HPRD 11864968


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K138 T138 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S156 N156 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]