iPTMnet Report Q86SG6 NEK8

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q86SG6 / NEK8_HUMAN
Protein Name	Serine/threonine-protein kinase Nek8
Gene Name	Name: NEK8 Synonyms:JCK,NEK12A;
Organism	Homo sapiens (Human)

PRO ID	PR:Q86SG6 DAG View
PRO Name	serine/threonine-protein kinase Nek8 (human)
Definition	A serine/threonine-protein kinase Nek8 that is encoded in the genome of human.
Short Label	hNEK8
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q86SG6 (NEK8) as Substrate

Q86SG6

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T131	Phosphorylation		score2	HPRD PhosphoSitePlus	18491316
	K138	Ubiquitination		score1	PhosphoSitePlus
	S151	Phosphorylation		score1	PhosphoSitePlus
	K152	Ubiquitination		score1	PhosphoSitePlus
	S156	Phosphorylation		score1	PhosphoSitePlus
	S158	Phosphorylation		score1	PhosphoSitePlus
	T162	Phosphorylation		score4	HPRD PhosphoSitePlus RLIMS-P	22106379, 11864968
	T162	Phosphorylation	Q86SG6 (NEK8)	score1	HPRD	11864968
	C450	Methylation		score1	IEDB	31844290
	K639	Ubiquitination		score1	PhosphoSitePlus

Q86SG6 (NEK8) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	Q86SG6 (NEK8)	T162	score1	HPRD	11864968

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K138	T138	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S156	N156	Biomuta		DOID:10534 / stomach cancer [ cosmic, icgc ]