iPTMnet Report for Q7Z6J9 (TSEN54)
Protein Information
UniProt AC / UniProt ID | Q7Z6J9 / SEN54_HUMAN |
Protein Name | tRNA-splicing endonuclease subunit Sen54 |
Gene Name | Name: TSEN54 Synonyms:SEN54; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q7Z6J9 |
PRO Name | tRNA-splicing endonuclease subunit Sen54 (human) |
Definition | A tRNA-splicing endonuclease subunit Sen54 that is encoded in the genome of human. |
Short Label | hTSEN54 |
Category | organism-gene |
Q7Z6J9 (TSEN54) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
S178 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
Y180 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K199 | Acetylation | score1 | PhosphoSitePlus | |||
S203 | Phosphorylation | score1 | PhosphoSitePlus | |||
S204 | Phosphorylation | score1 | PhosphoSitePlus | |||
S205 | Phosphorylation | score1 | PhosphoSitePlus | |||
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
S225 | Phosphorylation | score1 | PhosphoSitePlus | |||
S229 | Phosphorylation | score1 | PhosphoSitePlus | |||
S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
S235 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
S267 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
K293 | Acetylation | score1 | PhosphoSitePlus | |||
R316 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
K340 | Ubiquitination | score1 | PhosphoSitePlus | |||
K382 | Ubiquitination | score1 | PhosphoSitePlus | |||
S443 | Phosphorylation | score1 | PhosphoSitePlus | |||
K489 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S178 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S225 | Phosphorylation | score0 | HPRD | 19413330 | ||
S230 | Phosphorylation | score0 | HPRD | 17525332 | ||
S235 | Phosphorylation | score0 | HPRD | 17525332 | ||
S249 | Phosphorylation | score0 | HPRD | 19413330 | ||
S267 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S204 | T204 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
K382 | Q382 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
S443 | C443 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |