Protein Information

Cytoscape View

UniProt AC / UniProt ID Q7Z6J9 / SEN54_HUMAN
Protein Name tRNA-splicing endonuclease subunit Sen54
Gene Name Name: TSEN54
Organism Homo sapiens (Human)

DAG View
PRO Name tRNA-splicing endonuclease subunit Sen54 (human)
Definition A tRNA-splicing endonuclease subunit Sen54 that is encoded in the genome of human.
Short Label hTSEN54
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q7Z6J9 (TSEN54) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S76 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y180 Phosphorylation PhosphoSitePlus   UniProt 23186163
K199 Acetylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S235 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S249 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K293 Acetylation PhosphoSitePlus
R316 Methylation PhosphoSitePlus   UniProt 24129315
K340 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S178 Phosphorylation HPRD 18669648, 20068231
S225 Phosphorylation HPRD 19413330
S230 Phosphorylation HPRD 17525332
S235 Phosphorylation HPRD 17525332
S249 Phosphorylation HPRD 19413330
S267 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S204 T204 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K382 Q382 Biomuta DOID:5041 / esophageal cancer [ icgc ]