iPTMnet Report for Q7Z6J9 (TSEN54)
Protein Information
| UniProt AC / UniProt ID | Q7Z6J9 / SEN54_HUMAN |
| Protein Name | tRNA-splicing endonuclease subunit Sen54 |
| Gene Name | Name: TSEN54 Synonyms:SEN54; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q7Z6J9 |
| PRO Name | tRNA-splicing endonuclease subunit Sen54 (human) |
| Definition | A tRNA-splicing endonuclease subunit Sen54 that is encoded in the genome of human. |
| Short Label | hTSEN54 |
| Category | organism-gene |
DAG ViewQ7Z6J9 (TSEN54) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K97 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S178 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
| Y180 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K199 | Acetylation | score1 | PhosphoSitePlus | |||
| S203 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S204 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S205 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S229 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S230 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
| S235 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
| S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S267 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231 | ||
| K293 | Acetylation | score1 | PhosphoSitePlus | |||
| R316 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| K340 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K382 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S443 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K489 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S178 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S225 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S230 | Phosphorylation | score0 | HPRD | 17525332 | ||
| S235 | Phosphorylation | score0 | HPRD | 17525332 | ||
| S249 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S267 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S204 | T204 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| K382 | Q382 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| S443 | C443 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] |
