iPTMnet Report for Q7Z628 (NET1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z628 / ARHG8_HUMAN
Protein Name Neuroepithelial cell-transforming gene 1 protein
Gene Name Name: NET1
Synonyms:ARHGEF8;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z628
DAG View
PRO Name neuroepithelial cell-transforming gene 1 protein (human)
Definition A neuroepithelial cell-transforming gene 1 protein that is encoded in the genome of human.
Short Label hNET1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z628 (NET1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K9 Ubiquitination PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S24 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus   UniProt 19690332
T35 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S100 Phosphorylation Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 26456332
S106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T119 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus   UniProt 23186163
R126 Methylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S152 Phosphorylation Q13153 (PAK1) neXtProt   RLIMS-P 15684429, 18509476
Y180 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
T329 Phosphorylation IEDB 35494241
K357 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
R453 Methylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T540 Phosphorylation PhosphoSitePlus
K567 Sumoylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K570 Sumoylation PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S100 Phosphorylation HPRD 18669648
S106 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation HPRD 18669648
S52 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 F52 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S78 G78 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K85 R85 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S106 F106 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S122 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R126 C126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S451 C451 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
R453 Q453 Biomuta DOID:263 / kidney cancer [ cosmic ]
T533 A533 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S539 F539 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]