iPTMnet Report for Q7Z5H3 (ARHGAP22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z5H3 / RHG22_HUMAN
Protein Name Rho GTPase-activating protein 22
Gene Name Name: ARHGAP22
Synonyms:RHOGAP2;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z5H3
DAG View
PRO Name Rho GTPase-activating protein 22 (human)
Definition A Rho GTPase-activating protein 22 that is encoded in the genome of human.
Short Label hARHGAP22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z5H3 (ARHGAP22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P 21969604
S209 Phosphorylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus   UniProt 23186163
S372 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus   UniProt 23186163
T424 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
K648 Methylation PhosphoSitePlus
Y649 Phosphorylation PhosphoSitePlus
K655 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S394 Phosphorylation HPRD 18578522
S395 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 Y14 Biomuta DOID:10283 / prostate cancer [ icgc ]
S209 F209 Biomuta DOID:4159 / skin cancer [ cosmic ]
S394 C394 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S395 F395 Biomuta DOID:4159 / skin cancer [ cosmic ]
T424 S424 Biomuta DOID:263 / kidney cancer [ cosmic ]
S439 L439 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S467 T467 Biomuta DOID:1324 / lung cancer [ cosmic ]
S476 L476 Biomuta DOID:4159 / skin cancer [ cosmic ]
S636 P636 Biomuta DOID:2531 / hematologic cancer [ icgc ]