iPTMnet Report for Q7Z5H3 (ARHGAP22)
Protein Information
| UniProt AC / UniProt ID | Q7Z5H3 / RHG22_HUMAN |
| Protein Name | Rho GTPase-activating protein 22 |
| Gene Name | Name: ARHGAP22 Synonyms:RHOGAP2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q7Z5H3 |
| PRO Name | Rho GTPase-activating protein 22 (human) |
| Definition | A Rho GTPase-activating protein 22 that is encoded in the genome of human. |
| Short Label | hARHGAP22 |
| Category | organism-gene |
DAG ViewQ7Z5H3 (ARHGAP22) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S16 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P | 21969604 | ||
| S16 | Phosphorylation | P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus | 21969604 | |
| S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T221 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T310 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S346 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S359 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S394 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S395 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T424 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S439 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S467 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S476 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S587 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S636 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K648 | Acetylation | score1 | PhosphoSitePlus | |||
| K648 | Methylation | score1 | PhosphoSitePlus | |||
| Y649 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K655 | Acetylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S394 | Phosphorylation | score0 | HPRD | 18578522 | ||
| S395 | Phosphorylation | score0 | HPRD | 19413330 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S7 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S14 | Y14 | Biomuta | DOID:10283 / prostate cancer [ icgc ] | |
| S209 | F209 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S394 | C394 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| S394 | F394 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| S395 | F395 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T424 | S424 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S439 | L439 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S467 | T467 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S476 | L476 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S636 | P636 | Biomuta | DOID:2531 / hematologic cancer [ icgc ] |
