iPTMnet Report for Q76LX8 (ADAMTS13)
Protein Information
UniProt AC / UniProt ID | Q76LX8 / ATS13_HUMAN |
Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 13 precursor |
Gene Name | Name: ADAMTS13 Synonyms:C9orf8;ORFNames:UNQ6102/PRO20085; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q76LX8 |
PRO Name | a disintegrin and metalloproteinase with thrombospondin motifs 13 (human) |
Definition | An a disintegrin and metalloproteinase with thrombospondin motifs 13 that is encoded in the genome of human. |
Short Label | hADAMTS13 |
Category | organism-gene |
Q76LX8 (ADAMTS13) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T358 | Phosphorylation | score1 | PhosphoSitePlus | |||
T435 | Phosphorylation | score1 | PhosphoSitePlus | |||
N552 | N-Glycosylation | score4 | GlyGen UniProt | 19880749, 29391424 | ||
N614 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 19880749, 23090970, ... | ||
N667 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970, 19139490 | ||
S696 | Phosphorylation | score1 | PhosphoSitePlus | |||
S698 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
N707 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 19139490, 29391424 | ||
S757 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
T779 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
T843 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
S863 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
S907 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
S965 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
S1027 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
S1087 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
T1135 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
S1137 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
T1150 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
T1153 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
S1158 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
N1235 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
T1294 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1296 | Phosphorylation | score1 | PhosphoSitePlus | |||
N1345 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
N1354 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970 | ||
S1356 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1357 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S272 | Phosphorylation | score1 | PhosphoSitePlus | |||
S275 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S698 | N698 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
N707 | K707 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
S863 | L863 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S1087 | F1087 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] | |
T1135 | M1135 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
Y1296 | * | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
N1345 | S1345 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y1357 | N1357 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |