Protein Information

Cytoscape View

UniProt AC / UniProt ID Q76LX8 / ATS13_HUMAN
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 13 precursor
Gene Name Name: ADAMTS13
Organism Homo sapiens (Human)

DAG View
PRO Name a disintegrin and metalloproteinase with thrombospondin motifs 13 (human)
Definition An a disintegrin and metalloproteinase with thrombospondin motifs 13 that is encoded in the genome of human.
Short Label hADAMTS13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q76LX8 (ADAMTS13) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T358 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
N552 N-Glycosylation GlyGen   UniProt 19880749, 29391424
N614 N-Glycosylation GlyGen   UniProt 16335952, 19880749, 23090970, ...29391424, 27574189
N667 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 19139490
S696 Phosphorylation PhosphoSitePlus
S698 O-Glycosylation GlyGen   UniProt 24977290, 17395589
S698 Phosphorylation PhosphoSitePlus
N707 N-Glycosylation GlyGen   UniProt 23090970, 19139490, 29391424
S757 O-Glycosylation GlyGen   UniProt 17395589
T779 O-Glycosylation GlyGen 30459171
T843 O-Glycosylation GlyGen 30459171
S863 O-Glycosylation GlyGen 30459171
S907 O-Glycosylation GlyGen   UniProt 24977290, 17395589
S965 O-Glycosylation GlyGen   UniProt 17395589
S1027 O-Glycosylation GlyGen   UniProt 17395589
S1087 O-Glycosylation GlyGen   UniProt 24977290, 17395589
T1135 O-Glycosylation GlyGen 30459171
S1137 O-Glycosylation GlyGen 30459171
T1150 O-Glycosylation GlyGen 30459171
T1153 O-Glycosylation GlyGen 30459171
S1158 O-Glycosylation GlyGen 30459171
N1235 N-Glycosylation GlyGen 29391424
T1294 Phosphorylation PhosphoSitePlus
Y1296 Phosphorylation PhosphoSitePlus
N1345 N-Glycosylation GlyGen 29391424
N1354 N-Glycosylation GlyGen   UniProt 16335952, 23090970
S1356 Phosphorylation PhosphoSitePlus
Y1357 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S272 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N707 K707 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1087 F1087 Biomuta DOID:1324 / lung cancer [ icgc ]
T1135 M1135 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1296 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]