iPTMnet Report for Q76LX8 (ADAMTS13)
Protein Information
| UniProt AC / UniProt ID | Q76LX8 / ATS13_HUMAN |
| Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 13 precursor |
| Gene Name | Name: ADAMTS13 Synonyms:C9orf8;ORFNames:UNQ6102/PRO20085; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q76LX8 |
| PRO Name | a disintegrin and metalloproteinase with thrombospondin motifs 13 (human) |
| Definition | An a disintegrin and metalloproteinase with thrombospondin motifs 13 that is encoded in the genome of human. |
| Short Label | hADAMTS13 |
| Category | organism-gene |
DAG ViewQ76LX8 (ADAMTS13) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T358 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T435 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N552 | N-Glycosylation | score4 | GlyGen UniProt | 19880749, 29391424 | ||
| N614 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 19880749, 23090970, ... | ||
| N667 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970, 19139490 | ||
| S696 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S698 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
| S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N707 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 19139490, 29391424 | ||
| S757 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
| T779 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| T843 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S863 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S907 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
| S965 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
| S1027 | O-Glycosylation | score3 | GlyGen UniProt | 17395589 | ||
| S1087 | O-Glycosylation | score4 | GlyGen UniProt | 24977290, 17395589 | ||
| T1135 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S1137 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| T1150 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| T1153 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S1158 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| N1235 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| T1294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1296 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N1345 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
| N1354 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970 | ||
| S1356 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1357 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S272 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S275 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S698 | N698 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| N707 | K707 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S863 | L863 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S1087 | F1087 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] | |
| T1135 | M1135 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] | |
| Y1296 | * | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| N1345 | S1345 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y1357 | N1357 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
