iPTMnet Report for Q76I76 (SSH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q76I76 / SSH2_HUMAN
Protein Name Protein phosphatase Slingshot homolog 2
Gene Name Name: SSH2
Synonyms:KIAA1725,SSH2L;
Organism Homo sapiens (Human)

PRO ID PR:Q76I76
DAG View
PRO Name protein phosphatase Slingshot homolog 2 (human)
Definition A protein phosphatase Slingshot homolog 2 that is encoded in the genome of human.
Short Label hSSH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q76I76 (SSH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
S36 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S40 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S463 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus   UniProt 19690332
K588 Ubiquitination PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
T666 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
S690 O-Glycosylation GlyGen 30379171
S690 Phosphorylation PhosphoSitePlus
S706 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
T754 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
T795 Phosphorylation PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
S1187 Phosphorylation PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1217 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1218 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus
T1249 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1259 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
Y1356 Phosphorylation PhosphoSitePlus
K1408 Acetylation PhosphoSitePlus
K1412 Acetylation PhosphoSitePlus
K1413 Acetylation PhosphoSitePlus
T1422 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 18669648, 20068231
S461 Phosphorylation HPRD 17081983
S487 Phosphorylation HPRD 19413330, 19664994
S734 Phosphorylation HPRD 20068231
S1216 Phosphorylation HPRD 20068231
S1217 Phosphorylation HPRD 19651622, 20068231
S1218 Phosphorylation HPRD 20068231
S1227 Phosphorylation HPRD 20068231
T1422 Phosphorylation HPRD 18669648, 15345747


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 I36 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S36 R36 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S63 R63 Biomuta DOID:3571 / liver cancer [ cosmic ]
K265 Q265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S399 L399 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S399 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S401 P401 Biomuta DOID:363 / uterine cancer [ icgc ]
Y411 N411 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y419 C419 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S466 L466 Biomuta DOID:1324 / lung cancer [ cosmic ]
S706 I706 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S784 N784 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S784 R784 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1259 Y1259 Biomuta DOID:363 / uterine cancer [ icgc ]
T1422 I1422 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]