iPTMnet Report for Q6XUX3 (DSTYK)
Protein Information
UniProt AC / UniProt ID | Q6XUX3 / DUSTY_HUMAN |
Protein Name | Dual serine/threonine and tyrosine protein kinase |
Gene Name | Name: DSTYK Synonyms:KIAA0472,RIP5,RIPK5,SGK496;ORFNames:HDCMD38P; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q6XUX3 |
PRO Name | dual serine/threonine and tyrosine protein kinase (human) |
Definition | A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human. |
Short Label | hDSTYK |
Category | organism-gene |
Q6XUX3 (DSTYK) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
R29 | Methylation | score1 | PhosphoSitePlus | |||
K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
S286 | Phosphorylation | score1 | PhosphoSitePlus | |||
R294 | Methylation | score1 | PhosphoSitePlus | |||
K339 | Ubiquitination | score1 | PhosphoSitePlus | |||
T353 | Phosphorylation | score1 | PhosphoSitePlus | |||
K389 | Ubiquitination | score1 | PhosphoSitePlus | |||
K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
K479 | Ubiquitination | score1 | PhosphoSitePlus | |||
S490 | O-Glycosylation | score1 | GlyGen | 29485866, 30620550 | ||
K567 | Ubiquitination | score1 | PhosphoSitePlus | |||
S575 | Phosphorylation | score1 | PhosphoSitePlus | |||
S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
S579 | Phosphorylation | score1 | PhosphoSitePlus | |||
K580 | Ubiquitination | score1 | PhosphoSitePlus | |||
K617 | Ubiquitination | score1 | PhosphoSitePlus | |||
K781 | Ubiquitination | score1 | PhosphoSitePlus | |||
K787 | Ubiquitination | score1 | PhosphoSitePlus | |||
K824 | Acetylation | score1 | PhosphoSitePlus | |||
K915 | Ubiquitination | score1 | PhosphoSitePlus | |||
S928 | Phosphorylation | score1 | PhosphoSitePlus | |||
T929 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K792 | Methylation | score1 | PhosphoSitePlus | |||
K800 | Methylation | score1 | PhosphoSitePlus | |||
R825 | Methylation | score1 | PhosphoSitePlus | |||
R828 | Methylation | score1 | PhosphoSitePlus | |||
S883 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R29 | G29 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S286 | L286 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
S490 | N490 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S575 | R575 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K781 | E781 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
K787 | T787 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K792 | N792 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K800 | N800 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
R825 | H825 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
R828 | C828 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] | |
K915 | N915 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |