iPTMnet Report for Q6XUX3 (DSTYK)
Protein Information
| UniProt AC / UniProt ID | Q6XUX3 / DUSTY_HUMAN |
| Protein Name | Dual serine/threonine and tyrosine protein kinase |
| Gene Name | Name: DSTYK Synonyms:KIAA0472,RIP5,RIPK5,SGK496;ORFNames:HDCMD38P; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q6XUX3 |
| PRO Name | dual serine/threonine and tyrosine protein kinase (human) |
| Definition | A dual serine/threonine and tyrosine protein kinase that is encoded in the genome of human. |
| Short Label | hDSTYK |
| Category | organism-gene |
Q6XUX3 (DSTYK) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| R29 | Methylation | score1 | PhosphoSitePlus | |||
| K56 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R294 | Methylation | score1 | PhosphoSitePlus | |||
| K339 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K389 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K397 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K479 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S490 | O-Glycosylation | score1 | GlyGen | 29485866, 30620550 | ||
| K567 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S575 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S579 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K580 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K617 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K781 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K787 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K824 | Acetylation | score1 | PhosphoSitePlus | |||
| K915 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S928 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T929 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K792 | Methylation | score1 | PhosphoSitePlus | |||
| K800 | Methylation | score1 | PhosphoSitePlus | |||
| R825 | Methylation | score1 | PhosphoSitePlus | |||
| R828 | Methylation | score1 | PhosphoSitePlus | |||
| S883 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R29 | G29 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S286 | L286 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S490 | N490 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S575 | R575 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K781 | E781 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| K787 | T787 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K792 | N792 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K800 | N800 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| R825 | H825 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| R828 | C828 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| K915 | N915 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View