Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6VAB6 / KSR2_HUMAN
Protein Name Kinase suppressor of Ras 2
Gene Name Name: KSR2
Organism Homo sapiens (Human)

PRO ID PR:Q6VAB6
DAG View
PRO Name kinase suppressor of Ras 2 (human)
Definition A kinase suppressor of Ras 2 that is encoded in the genome of human.
Short Label hKSR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6VAB6 (KSR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S34 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
K281 Acetylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
Y566 Phosphorylation PhosphoSitePlus
Y794 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus


Q6VAB6 (KSR2) as PTM Enzyme



Substrate Site Score Source PMID
Q02750 (MAP2K1) S24 neXtProt 21441910
Q02750 (MAP2K1) S72 neXtProt 21441910


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T270 I270 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T276 M276 Biomuta DOID:0070003 / blastoma [ cosmic ]
S294 F294 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S311 N311 Biomuta DOID:1324 / lung cancer [ tcga ]
S313 Y313 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S347 R347 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S399 F399 Biomuta DOID:363 / uterine cancer [ tcga ]
T802 M802 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]