iPTMnet Report for Q6IA69 (NADSYN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q6IA69 / NADE_HUMAN
Protein Name Glutamine-dependent NAD(+) synthetase
Gene Name Name: NADSYN1
Organism Homo sapiens (Human)

PRO ID PR:Q6IA69
DAG View
PRO Name glutamine-dependent NAD(+) synthetase (human)
Definition A glutamine-dependent NAD(+) synthetase that is encoded in the genome of human.
Short Label hNADSYN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q6IA69 (NADSYN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
S308 Phosphorylation IEDB 35494241
K421 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
T427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
Y657 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y227 H227 Biomuta DOID:4159 / skin cancer [ cosmic ]
S308 L308 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S423 T423 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S424 F424 Biomuta DOID:4159 / skin cancer [ cosmic ]
T427 M427 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K642 N642 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y643 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y657 H657 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]