iPTMnet Report for Q687X5 (STEAP4)
Protein Information
| UniProt AC / UniProt ID | Q687X5 / STEA4_HUMAN |
| Protein Name | Metalloreductase STEAP4 |
| Gene Name | Name: STEAP4 Synonyms:STAMP2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q687X5 |
| PRO Name | metalloreductase STEAP4 (human) |
| Definition | A metalloreductase STEAP4 that is encoded in the genome of human. |
| Short Label | hSTEAP4 |
| Category | organism-gene |
DAG ViewQ687X5 (STEAP4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K3 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K54 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K72 | Acetylation | score1 | PhosphoSitePlus | |||
| K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K161 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T176 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S182 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y225 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N323 | N-Glycosylation | score4 | GlyGen UniProt | 30337524, 19159218 | ||
| S408 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q05397 (PTK2) | Y397 | Q687X5 (STEAP4) | unknown | eFIP | 31648990 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S33 | L33 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc, tcga ] | |
| Y225 | F225 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y225 | C225 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
