iPTMnet Report for Q687X5 (STEAP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q687X5 / STEA4_HUMAN
Protein Name Metalloreductase STEAP4
Gene Name Name: STEAP4
Synonyms:STAMP2;
Organism Homo sapiens (Human)

PRO ID PR:Q687X5
DAG View
PRO Name metalloreductase STEAP4 (human)
Definition A metalloreductase STEAP4 that is encoded in the genome of human.
Short Label hSTEAP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q687X5 (STEAP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Ubiquitination PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
N323 N-Glycosylation GlyGen   UniProt 30337524, 19159218
S408 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q05397 (PTK2) Y397 Q687X5 (STEAP4) unknown eFIP 31648990


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 L33 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
Y225 F225 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y225 C225 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]