iPTMnet Report for Q5XUX0 (FBXO31)
Protein Information
| UniProt AC / UniProt ID | Q5XUX0 / FBX31_HUMAN |
| Protein Name | F-box only protein 31 |
| Gene Name | Name: FBXO31 Synonyms:FBX14,FBX31;ORFNames:PP2386; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q5XUX0 |
| PRO Name | F-box only protein 31 (human) |
| Definition | An F-box only protein 31 that is encoded in the genome of human. |
| Short Label | hFBXO31 |
| Category | organism-gene |
DAG ViewQ5XUX0 (FBXO31) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| R14 | Methylation | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29343641 | ||
| T37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T127 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y135 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K229 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y276 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T277 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S278 | Phosphorylation | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 29343641, 19412162, 30171069 | ||
| S278 | Phosphorylation | Q13315 (ATM) | score3 | neXtProt PhosphoSitePlus Signor | 19412162 | |
| C283 | Methylation | score1 | IEDB | 31844290 | ||
| T285 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y309 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S311 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P24385 (CCND1) | T286 | Q5XUX0 (FBXO31) | unknown | eFIP | 19412162 | |
| Phosphorylation | Q5XUX0 (FBXO31) | S278 | Q12834 (CDC20) | inhibited_association | eFIP | 29343641 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T127 | A127 | Biomuta | DOID:1612 / breast cancer [ icgc ] | |
| Y135 | C135 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| Y276 | N276 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| C283 | Y283 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| T308 | A308 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y309 | C309 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S311 | N311 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
