iPTMnet Report for Q5XUX0 (FBXO31)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q5XUX0 / FBX31_HUMAN
Protein Name F-box only protein 31
Gene Name Name: FBXO31
Synonyms:FBX14,FBX31;ORFNames:PP2386;
Organism Homo sapiens (Human)

PRO ID PR:Q5XUX0
DAG View
PRO Name F-box only protein 31 (human)
Definition An F-box only protein 31 that is encoded in the genome of human.
Short Label hFBXO31
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q5XUX0 (FBXO31) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R14 Methylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus   RLIMS-P 29343641
T37 Phosphorylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29343641, 19412162, 30171069
C283 Methylation IEDB 31844290
T285 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P24385 (CCND1) T286 Q5XUX0 (FBXO31) unknown eFIP 19412162
Phosphorylation Q5XUX0 (FBXO31) S278 Q12834 (CDC20) inhibited_association eFIP 29343641


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T127 A127 Biomuta DOID:1612 / breast cancer [ icgc ]
Y135 C135 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y276 N276 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C283 Y283 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T308 A308 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y309 C309 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S311 N311 Biomuta DOID:9256 / colorectal cancer [ cosmic ]