iPTMnet Report for Q2M2I8 (AAK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q2M2I8 / AAK1_HUMAN
Protein Name AP2-associated protein kinase 1
Gene Name Name: AAK1
Synonyms:KIAA1048;
Organism Homo sapiens (Human)

PRO ID PR:Q2M2I8
DAG View
PRO Name AP2-associated protein kinase 1 (human)
Definition An AAK1 gene translation product (human), isoforms h1 and h2.
Short Label hAAK1/[h1/h2]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


Q2M2I8 (AAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S7 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S18 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S26 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
T170 Phosphorylation RLIMS-P 26853940
K178 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
T207 Phosphorylation RLIMS-P 26853940
K219 Ubiquitination PhosphoSitePlus
T221 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T222 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y234 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S235 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26853940, 18669648
Y253 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
K317 Methylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
T354 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T354 Phosphorylation PhosphoSitePlus   UniProt 19369195
T359 O-Glycosylation GlyGen 34019948, 28657654, 29351928, ...35132862, 30620550, 31373491, 22564745, 35254053, 36731797
T359 Phosphorylation PhosphoSitePlus
T360 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T362 Phosphorylation PhosphoSitePlus
S363 O-Glycosylation GlyGen 31373491
T375 Phosphorylation PhosphoSitePlus
T389 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18234856, 16964243, ...18691976, 18220336, 18669648, 19690332
T389 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 18234856
R391 Methylation PhosphoSitePlus
T441 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T441 Phosphorylation PhosphoSitePlus   UniProt 18691976
T445 O-Glycosylation GlyGen 32938750, 34019948, 28657654, ...29351928, 35132862, 30620550, 22564745, 35254053, 36731797
S447 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T448 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T507 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
S519 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
T605 Phosphorylation PhosphoSitePlus
T606 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 18344231, 19690332
S618 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T620 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 23186163, ...22238634, 18669648, 24275569, 18344231, 20068231
S623 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S624 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 18344231, ...18669648, 20068231
T627 Phosphorylation PhosphoSitePlus
S637 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18691976, 19367720, 18669648, 22445341, 32387766, 19690332, 20068231
S637 Phosphorylation Q15208 (STK38) neXtProt 22445341
T640 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S642 Phosphorylation PhosphoSitePlus
S650 O-Glycosylation GlyGen 35132862, 28657654, 29351928, ...34019948, 30620550, 22564745, 35254053, 36731797
S650 Phosphorylation PhosphoSitePlus   UniProt 19369195
S652 Phosphorylation PhosphoSitePlus
T653 Phosphorylation PhosphoSitePlus   UniProt 19690332
S664 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
S670 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T672 Phosphorylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
S676 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S678 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S682 Phosphorylation PhosphoSitePlus
Y687 Phosphorylation PhosphoSitePlus   UniProt 19369195
S690 Phosphorylation PhosphoSitePlus
K705 Acetylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus   UniProt 18691976, 19369195
S797 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
T852 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 18691976
S18 Phosphorylation HPRD 18691976
S20 Phosphorylation HPRD 18691976
S21 Phosphorylation HPRD 18669648
T27 Phosphorylation HPRD 18691976
T221 Phosphorylation HPRD 18669648
T222 Phosphorylation HPRD 18669648
Y234 Phosphorylation HPRD 18669648
S235 Phosphorylation HPRD 18669648
Y292 Phosphorylation HPRD 19664994
S327 Phosphorylation HPRD 18691976
T389 Phosphorylation HPRD 18691976, 18669648, 16964243
T441 Phosphorylation HPRD 18691976
T606 Phosphorylation HPRD 19413330, 18691976, 16964243, ...15302935, 19664994, 19664995, 18669648, 20068231
S618 Phosphorylation HPRD 18691976, 18669648, 20058876, ...20068231
T620 Phosphorylation HPRD 19413330, 18691976, 16083285, ...20058876, 19664995, 19651622, 18669648, 19415658, 20068231
S623 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19664995, 19651622, 18669648, 19415658, 20068231
S624 Phosphorylation HPRD 19413330, 17081983, 20058876, ...19664995, 19651622, 18669648, 20068231
S637 Phosphorylation HPRD 18691976, 18212344, 20058876, ...19651622, 18669648, 20068231
T640 Phosphorylation HPRD 18767875, 18669648, 20068231
S668 Phosphorylation HPRD 18691976
S670 Phosphorylation HPRD 19651622, 18691976
T674 Phosphorylation HPRD 19651622, 18691976
S676 Phosphorylation HPRD 19651622, 18691976, 19664995
S678 Phosphorylation HPRD 19651622, 18691976
T681 Phosphorylation HPRD 18691976
S682 Phosphorylation HPRD 18691976
S731 Phosphorylation HPRD 18691976, 20058876


Q2M2I8 (AAK1) as PTM Enzyme



Substrate Site Score Source PMID
P49757 (NUMB) T102 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18657069
Q96CW1 (AP2M1) T156 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11877457, 11877461
Q9BXS5 (AP1M1) T144 phospho.ELM   Signor 11877461


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K88 N88 Biomuta DOID:4159 / skin cancer [ cosmic ]
K178 N178 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T207 I207 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T222 M222 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K317 N317 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T354 I354 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T653 A653 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S678 C678 Biomuta DOID:1612 / breast cancer [ cosmic ]
T848 M848 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]