Protein Information

Cytoscape View


UniProt AC / UniProt ID Q2M2I8 / AAK1_HUMAN
Protein Name AP2-associated protein kinase 1
Gene Name Name: AAK1
Synonyms:KIAA1048;
Organism Homo sapiens (Human)

PRO ID PR:Q2M2I8
DAG View
PRO Name AP2-associated protein kinase 1 (human)
Definition An AP2-associated protein kinase 1 that is encoded in the genome of human.
Short Label hAAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q2M2I8 (AAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S7 Phosphorylation PhosphoSitePlus
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19369195, 23186163, 18691976
S18 Phosphorylation HPRD   PhosphoSitePlus 18691976
S20 Phosphorylation HPRD   PhosphoSitePlus 18691976
S21 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S26 Phosphorylation PhosphoSitePlus
T27 Phosphorylation HPRD 18691976
Y34 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
T170 Phosphorylation RLIMS-P 26853940
K178 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
T207 Phosphorylation RLIMS-P 26853940
K219 Ubiquitination PhosphoSitePlus
T221 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T222 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y234 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S235 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26853940, 18669648
Y253 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation HPRD   PhosphoSitePlus 19664994
K317 Methylation PhosphoSitePlus
S327 Phosphorylation HPRD   PhosphoSitePlus 18691976
T347 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus   UniProt 19369195
T359 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
T389 Phosphorylation P06493 (CDK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18234856, 16964243, ...19369195, 18220336, 18669648, 19690332
R391 Methylation PhosphoSitePlus
T441 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
T605 Phosphorylation PhosphoSitePlus
T606 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 21406692, ...23186163, 16964243, 15302935, 19664994, 19664995, 18669648, 18344231, 19690332, 20068231
S618 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20058876, ...20068231
T620 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 16083285, ...23186163, 22238634, 18691976, 20058876, 19664995, 19651622, 18669648, 24275569, 18344231, 19415658, 20068231
S623 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 18691976, ...19664995, 19651622, 18669648, 19415658, 20068231
S624 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 16083285, ...18344231, 17081983, 20058876, 19664995, 19651622, 18669648, 20068231
T627 Phosphorylation PhosphoSitePlus
S637 Phosphorylation Q15208 (STK38) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...18212344, 18691976, 20058876, 19651622, 19367720, 18669648, 22445341, 19690332, 20068231
T640 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18767875, 18669648, 20068231
S642 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus   UniProt 19369195
S652 Phosphorylation PhosphoSitePlus
T653 Phosphorylation PhosphoSitePlus   UniProt 19690332
S664 Phosphorylation PhosphoSitePlus
S668 Phosphorylation HPRD   PhosphoSitePlus 18691976
S670 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935, 18691976
T672 Phosphorylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
T674 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18691976
S676 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935, 19664995, ...18691976
S678 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 15302935, 18691976
T681 Phosphorylation HPRD 18691976
S682 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y687 Phosphorylation PhosphoSitePlus   UniProt 19369195
S690 Phosphorylation PhosphoSitePlus
K705 Acetylation PhosphoSitePlus
S731 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20058876, 19369195
S797 Phosphorylation PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
T852 Phosphorylation PhosphoSitePlus
S951 Phosphorylation PhosphoSitePlus


Q2M2I8 (AAK1) as PTM Enzyme



Substrate Site Score Source PMID
P49757 (NUMB) T102 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18657069
Q96CW1 (AP2M1) T156 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11877457, 11877461
Q9BXS5 (AP1M1) T144 phospho.ELM   Signor 11877461


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T207 I207 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T222 M222 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T347 A347 Biomuta DOID:363 / uterine cancer [ tcga ]
T605 K605 Biomuta DOID:3571 / liver cancer [ icgc ]
T653 A653 Biomuta DOID:1909 / melanoma [ cosmic ]
T672 P672 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S678 C678 Biomuta DOID:1612 / breast cancer [ cosmic ]