iPTMnet Report for Q16719 (KYNU)
Protein Information
| UniProt AC / UniProt ID | Q16719 / KYNU_HUMAN |
| Protein Name | Kynureninase |
| Gene Name | Name: KYNU |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q16719 |
| PRO Name | kynureninase (human) |
| Definition | A kynureninase that is encoded in the genome of human. |
| Short Label | hKYNU |
| Category | organism-gene |
DAG ViewQ16719 (KYNU) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K21 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C45 | Methylation | score1 | IEDB | 31844290 | ||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K96 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K106 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T111 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S174 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K299 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K385 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C401 | Methylation | score1 | IEDB | 31844290 | ||
| K420 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K427 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S460 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T463 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K464 | Acetylation | score1 | PhosphoSitePlus | |||
| K464 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S5 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T111 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S115 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T297 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T365 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S460 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T463 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T12 | R12 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| C45 | Y45 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| C45 | R45 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K64 | E64 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| K121 | N121 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K157 | N157 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T297 | M297 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K385 | E385 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| C401 | F401 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K464 | N464 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
