iPTMnet Report for Q16656 (NRF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16656 / NRF1_HUMAN
Protein Name Nuclear respiratory factor 1
Gene Name Name: NRF1
Organism Homo sapiens (Human)

PRO ID PR:Q16656
DAG View
PRO Name nuclear respiratory factor 1 (human)
Definition A nuclear respiratory factor 1 that is encoded in the genome of human.
Short Label hNRF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16656 (NRF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation UniProt 9228045
S44 Phosphorylation UniProt 9228045
S46 Phosphorylation UniProt 9228045
S47 Phosphorylation RLIMS-P   UniProt 16864783, 9228045
S52 Phosphorylation UniProt 9228045
T87 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   RLIMS-P 31350280
T109 Phosphorylation RLIMS-P 25965299
T118 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus   RLIMS-P 31350280
S138 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus   RLIMS-P 30642892
K267 Ubiquitination PhosphoSitePlus
T294 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
S296 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
S303 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
T369 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
S432 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
T443 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511
S457 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 29351928, 34019948, 29485866, 32119511


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 L44 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
S46 F46 Biomuta DOID:4159 / skin cancer [ cosmic ]
S47 L47 Biomuta DOID:4159 / skin cancer [ cosmic ]
S102 F102 Biomuta DOID:4159 / skin cancer [ cosmic ]
T109 A109 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T118 M118 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T123 S123 Biomuta DOID:1324 / lung cancer [ cosmic ]
K230 M230 Biomuta DOID:1324 / lung cancer [ cosmic ]
K230 N230 Biomuta DOID:4159 / skin cancer [ cosmic ]
S303 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T369 I369 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S432 F432 Biomuta DOID:3571 / liver cancer [ cosmic ]