iPTMnet Report for Q16143 (SNCB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q16143 / SYUB_HUMAN
Protein Name Beta-synuclein
Gene Name Name: SNCB
Organism Homo sapiens (Human)

PRO ID PR:Q16143
DAG View
PRO Name beta-synuclein (human)
Definition A beta-synuclein that is encoded in the genome of human.
Short Label hSNCB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q16143 (SNCB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
T27 O-Glycosylation GlyGen 28657654
Y39 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S54 O-Glycosylation GlyGen 28657654
T59 O-Glycosylation GlyGen 28657654
S118 Phosphorylation HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 10852916, 19889641
S118 Phosphorylation P34947 (GRK5) HPRD   neXtProt 10852916
S118 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 19889641
S118 Phosphorylation Q9H4B4 (PLK3) neXtProt   PhosphoSitePlus   Signor 19889641
S118 Phosphorylation Q9NYY3 (PLK2) neXtProt   PhosphoSitePlus   Signor 19889641
Y127 Phosphorylation PhosphoSitePlus   Signor 21699177
Y127 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   Signor 21699177


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 T12 Biomuta DOID:1324 / lung cancer [ cosmic ]
K21 N21 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y39 C39 Biomuta DOID:263 / kidney cancer [ cosmic ]
T59 N59 Biomuta DOID:9256 / colorectal cancer [ cosmic ]