iPTMnet Report Q15569 TESK1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q15569 / TESK1_HUMAN
Protein Name	Dual specificity testis-specific protein kinase 1
Gene Name	Name: TESK1
Organism	Homo sapiens (Human)

PRO ID	PR:Q15569 DAG View
PRO Name	dual specificity testis-specific protein kinase 1 (human)
Definition	A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human.
Short Label	hTESK1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q15569 (TESK1) as Substrate

Q15569

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	R37	Methylation		score1	PhosphoSitePlus
	S69	Phosphorylation		score1	PhosphoSitePlus
	K179	Ubiquitination		score1	PhosphoSitePlus
	K212	Ubiquitination		score1	PhosphoSitePlus
	S220	Phosphorylation	Q15569 (TESK1)	score3	HPRD phospho.ELM Signor	10207045
	R338	Methylation		score1	PhosphoSitePlus
	S342	Phosphorylation		score1	PhosphoSitePlus
	T344	Phosphorylation		score1	PhosphoSitePlus
	S357	Phosphorylation		score1	PhosphoSitePlus
	K391	Acetylation		score1	PhosphoSitePlus
	K393	Acetylation		score1	PhosphoSitePlus
	K400	Acetylation		score1	PhosphoSitePlus
	S437	Phosphorylation		score1	PhosphoSitePlus
	S441	Phosphorylation		score1	PhosphoSitePlus
	S540	Phosphorylation		score1	PhosphoSitePlus
	S553	Phosphorylation		score1	PhosphoSitePlus
	S603	Phosphorylation		score1	PhosphoSitePlus
	T616	Phosphorylation		score1	PhosphoSitePlus

Q15569 (TESK1) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P23528 (CFL1)	S3	score4	HPRD phospho.ELM PhosphoSitePlus Signor	11340065, 11294912, 18578522, ...18491316, 19413330, 18702456, 9655398, 20058876, 19651622, 18669648, 20068231, 11925442, 11418599, 15584898
	Q15569 (TESK1)	S220	score2	HPRD Signor	10207045
	Q9Y281 (CFL2)	S3	score1	Signor	11418599

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
R338	K338	Biomuta		DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T344	M344	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S437	*	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
S441	P441	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]