Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15569 / TESK1_HUMAN
Protein Name Dual specificity testis-specific protein kinase 1
Gene Name Name: TESK1
Organism Homo sapiens (Human)

PRO ID PR:Q15569
DAG View
PRO Name dual specificity testis-specific protein kinase 1 (human)
Definition A dual specificity testis-specific protein kinase 1 that is encoded in the genome of human.
Short Label hTESK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15569 (TESK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R37 Methylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
S220 Phosphorylation HPRD   phospho.ELM   Signor 10207045
S220 Phosphorylation Q15569 (TESK1) HPRD   Signor 10207045
R338 Methylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus
K400 Acetylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus


Q15569 (TESK1) as PTM Enzyme



Substrate Site Score Source PMID
P23528 (CFL1) S3 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11340065, 11294912, 18578522, ...18491316, 19413330, 18702456, 9655398, 20058876, 19651622, 18669648, 20068231, 11925442, 11418599, 15584898
Q15569 (TESK1) S220 HPRD   Signor 10207045
Q9Y281 (CFL2) S3 Signor 11418599


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R338 K338 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T344 M344 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S437 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S441 P441 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]