iPTMnet Report for Q15464 (SHB)
Protein Information
| UniProt AC / UniProt ID | Q15464 / SHB_HUMAN |
| Protein Name | SH2 domain-containing adapter protein B |
| Gene Name | Name: SHB |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15464 |
| PRO Name | SH2 domain-containing adapter protein B (human) |
| Definition | An SH2 domain-containing adapter protein B that is encoded in the genome of human. |
| Short Label | hSHB |
| Category | organism-gene |
DAG ViewQ15464 (SHB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Phosphorylation | score1 | PRO | ||||
| Y8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S18 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y27 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S102 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| Y114 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S129 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S154 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S158 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S165 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S211 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T213 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K218 | Acetylation | score1 | PhosphoSitePlus | |||
| T241 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y246 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15951569 | ||
| S247 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S265 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y268 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y272 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y297 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T299 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y301 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S307 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S310 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S312 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S314 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S317 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S323 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y336 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S363 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S388 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 18220336 | ||
| S437 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y485 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y502 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T508 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y114 | Phosphorylation | score0 | HPRD | 17389395 | ||
| Y246 | Phosphorylation | score0 | HPRD | 15951569, 18578522, 17389395, ... | ||
| Y268 | Phosphorylation | score0 | HPRD | 17389395 | ||
| S310 | Phosphorylation | score0 | HPRD | 19413330 | ||
| S312 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S314 | Phosphorylation | score0 | HPRD | 18669648 | ||
| S317 | Phosphorylation | score0 | HPRD | 18669648 | ||
| Y336 | Phosphorylation | score0 | HPRD | 17389395, 20068231 | ||
| S362 | Phosphorylation | score0 | HPRD | 19651622 | ||
| S367 | Phosphorylation | score0 | HPRD | 19651622, 20068231 | ||
| S388 | Phosphorylation | score0 | HPRD | 18669648 |
Q15464 (SHB) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S102 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S158 | F158 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S166 | R166 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T172 | M172 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S190 | N190 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y272 | C272 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y297 | C297 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S317 | N317 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] | |
| Y336 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| Y336 | C336 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S363 | P363 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ] | |
| S437 | N437 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] |
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