Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15464 / SHB_HUMAN
Protein Name SH2 domain-containing adapter protein B
Gene Name Name: SHB
Organism Homo sapiens (Human)

PRO ID PR:Q15464
DAG View
PRO Name SH2 domain-containing adapter protein B (human)
Definition An SH2 domain-containing adapter protein B that is encoded in the genome of human.
Short Label hSHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15464 (SHB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Y8 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y114 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 15951569, 32060095
S247 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus   RLIMS-P 32060095
T299 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus   UniProt 23186163
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S314 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S323 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus   RLIMS-P 32060095
S363 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S388 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S437 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y114 Phosphorylation HPRD 17389395
Y246 Phosphorylation HPRD 15951569, 18578522, 17389395, ...20068231
Y268 Phosphorylation HPRD 17389395
S310 Phosphorylation HPRD 19413330
S312 Phosphorylation HPRD 18669648
S314 Phosphorylation HPRD 18669648
S317 Phosphorylation HPRD 18669648
Y336 Phosphorylation HPRD 17389395, 20068231
S362 Phosphorylation HPRD 19651622
S367 Phosphorylation HPRD 19651622, 20068231
S388 Phosphorylation HPRD 18669648


Q15464 (SHB) as PTM Enzyme



Substrate Site Score Source PMID
P11362-14 (FGFR1) Y675 HPRD 12181353, 7516330, 8622701
P11362-3 (FGFR1) Y677 HPRD 12181353, 7516330, 8622701
P11362-7 (FGFR1) Y764 HPRD 12181353, 7516330, 8622701


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049229 (hSHB/PhosSer+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P14784 (IL2RB) Y536 Q15464 (SHB) unknown eFIP 12200137
Phosphorylation P26618 (Pdgfra) Y720 Q15464 (SHB) unknown eFIP 10837138
Phosphorylation P35968 (KDR) Y1175 Q15464 (SHB) unknown eFIP 15026417
Phosphorylation Q15464 (SHB) Y246 P16333 (NCK1) unknown eFIP 32060095


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S166 R166 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T172 M172 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S190 N190 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y272 S272 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y272 C272 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:11054 / urinary bladder cancer [ icgc, tcga ]
Y297 C297 Biomuta DOID:1324 / lung cancer [ cosmic ]
S317 N317 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S323 R323 Biomuta DOID:3571 / liver cancer [ icgc ]
Y336 * Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
S363 P363 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S437 N437 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]