iPTMnet Report for Q15437 (SEC23B)
Protein Information
| UniProt AC / UniProt ID | Q15437 / SC23B_HUMAN |
| Protein Name | Protein transport protein Sec23B |
| Gene Name | Name: SEC23B |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q15437 |
| PRO Name | protein transport protein Sec23B (human) |
| Definition | A protein transport protein Sec23B that is encoded in the genome of human. |
| Short Label | hSEC23B |
| Category | organism-gene |
DAG ViewQ15437 (SEC23B) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 22814378, 22223895 | ||
| C66 | Methylation | score1 | IEDB | 31844290 | ||
| K67 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S154 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S156 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| T168 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S186 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P Signor | 30596474 | ||
| S186 | Phosphorylation | O75385 (ULK1) | score1 | Signor | 30596474 | |
| K193 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K208 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K320 | Acetylation | score1 | PhosphoSitePlus | |||
| K320 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K331 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y333 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K363 | Acetylation | score1 | PhosphoSitePlus | |||
| T369 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S378 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| T381 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| T381 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S382 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S382 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T393 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
| K394 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T407 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T412 | Phosphorylation | score0 | HPRD | 20068231 | ||
| K431 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K564 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T615 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S617 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S627 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S629 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S641 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S642 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| S643 | O-Glycosylation | score2 | GlyGen | 29161034 | ||
| K671 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K684 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y707 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S715 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y734 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K760 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q15437 (SEC23B) | S186 | O94855 (SEC24D) | inhibited_association | eFIP | 30596474 | |
| Phosphorylation | Q15437 (SEC23B) | S186 | P53992 (SEC24C) | inhibited_association | eFIP | 30596474 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | V2 | Biomuta | [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| C66 | Y66 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| C66 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| C66 | F66 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T168 | I168 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K185 | T185 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S186 | N186 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K193 | N193 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| K309 | N309 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S378 | Y378 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T381 | S381 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K558 | Q558 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K564 | N564 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S617 | P617 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| K760 | Q760 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] |
