iPTMnet Report for Q15437 (SEC23B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15437 / SC23B_HUMAN
Protein Name Protein transport protein Sec23B
Gene Name Name: SEC23B
Organism Homo sapiens (Human)

PRO ID PR:Q15437
DAG View
PRO Name protein transport protein Sec23B (human)
Definition A protein transport protein Sec23B that is encoded in the genome of human.
Short Label hSEC23B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15437 (SEC23B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K67 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S186 Phosphorylation O75385 (ULK1) PhosphoSitePlus   RLIMS-P   Signor 30596474
K193 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
T393 Phosphorylation HPRD   PhosphoSitePlus 20068231
K394 Ubiquitination PhosphoSitePlus
T407 Phosphorylation HPRD 20068231
T412 Phosphorylation HPRD 20068231
K431 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
S715 Phosphorylation PhosphoSitePlus
Y734 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q15437 (SEC23B) S186 O94855 (SEC24D) inhibited_association eFIP 30596474


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
K185 T185 Biomuta DOID:363 / uterine cancer [ tcga ]
K309 N309 Biomuta DOID:363 / uterine cancer [ tcga ]
T381 S381 Biomuta DOID:1612 / breast cancer [ cosmic ]
K558 Q558 Biomuta DOID:1909 / melanoma [ cosmic ]
Y707 * Biomuta DOID:5041 / esophageal cancer [ icgc ]