iPTMnet Report for Q15382 (RHEB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15382 / RHEB_HUMAN
Protein Name GTP-binding protein Rheb precursor
Gene Name Name: RHEB
Synonyms:RHEB2;
Organism Homo sapiens (Human)

PRO ID PR:Q15382
DAG View
PRO Name GTP-binding protein Rheb (human)
Definition A GTP-binding protein Rheb that is encoded in the genome of human.
Short Label hRHEB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15382 (RHEB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination UniProt 30514904
Y14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
S130 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 21336308, 26622727
S130 Phosphorylation Q8IW41 (MAPKAPK5) neXtProt   PhosphoSitePlus 21336308
K135 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus


Q15382 (RHEB) as PTM Enzyme



Substrate Site Score Source PMID
P04049-1 (RAF1) S338 HPRD 16803888
P15056 (BRAF) S446 HPRD 18691976, 18452278, 19651622, ...18669648, 16803888, 20166139, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04049 (RAF1) S43 Q15382 (RHEB) decreased_association eFIP 9001246
Phosphorylation Q8N122 (RPTOR) S606 Q15382 (RHEB) inhibited_association eFIP 32015438


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 F16 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S140 P140 Biomuta DOID:363 / uterine cancer [ cosmic ]
K169 Q169 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S175 L175 Biomuta DOID:4159 / skin cancer [ cosmic ]