iPTMnet Report for Q15382 (RHEB)
Protein Information
UniProt AC / UniProt ID | Q15382 / RHEB_HUMAN |
Protein Name | GTP-binding protein Rheb precursor |
Gene Name | Name: RHEB Synonyms:RHEB2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q15382 |
PRO Name | GTP-binding protein Rheb (human) |
Definition | A GTP-binding protein Rheb that is encoded in the genome of human. |
Short Label | hRHEB |
Category | organism-gene |
Q15382 (RHEB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K8 | Ubiquitination | score2 | UniProt | 30514904 | ||
Y14 | Phosphorylation | score1 | PhosphoSitePlus | |||
S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
K102 | Ubiquitination | score1 | PhosphoSitePlus | |||
K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
K120 | Ubiquitination | score1 | PhosphoSitePlus | |||
K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
S130 | Phosphorylation | Q8IW41 (MAPKAPK5) | score4 | neXtProt PhosphoSitePlus RLIMS-P | 21336308, 26622727 | |
K135 | Ubiquitination | score1 | PhosphoSitePlus | |||
S140 | Phosphorylation | score1 | PhosphoSitePlus | |||
K151 | Ubiquitination | score1 | PhosphoSitePlus | |||
K169 | Ubiquitination | score1 | PhosphoSitePlus | |||
S175 | Phosphorylation | score1 | PhosphoSitePlus |
Q15382 (RHEB) as PTM Enzyme
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P04049 (RAF1) | S43 | Q15382 (RHEB) | decreased_association | eFIP | 9001246 | |
Phosphorylation | Q8N122 (RPTOR) | S606 | Q15382 (RHEB) | inhibited_association | eFIP | 32015438 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S16 | F16 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
S140 | P140 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K169 | Q169 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
S175 | L175 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |