Protein Information

Cytoscape View


UniProt AC / UniProt ID Q15366 / PCBP2_HUMAN
Protein Name Poly(rC)-binding protein 2
Gene Name Name: PCBP2
Organism Homo sapiens (Human)

PRO ID PR:Q15366
DAG View
PRO Name poly(rC)-binding protein 2 (human)
Definition A poly(rC)-binding protein 2 that is encoded in the genome of human.
Short Label hPCBP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q15366 (PCBP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
K23 Sumoylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Sumoylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
C54 S-Nitrosylation dbSNO 19483679
T65 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
C109 S-Nitrosylation dbSNO 19483679
S111 Phosphorylation PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
C158 S-Nitrosylation dbSNO 19483679
K160 Ubiquitination PhosphoSitePlus
S173 Phosphorylation P11274 (BCR) , P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 21406692, 23186163, 17081983, ...17475908, 18669648, 20068231
T179 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S187 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S188 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S189 Phosphorylation P11274 (BCR) , P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 17081983, 17475908, 18669648, ...19690332, 20068231
T202 Phosphorylation PhosphoSitePlus
T213 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P11274 (BCR) PhosphoSitePlus   RLIMS-P+   Signor 17475908
Y230 Phosphorylation PhosphoSitePlus
T231 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
K245 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S271 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S272 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P11274 (BCR) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 17475908, 18669648
K276 Sumoylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Sumoylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
R314 Methylation PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S365 Phosphorylation PhosphoSitePlus   UniProt 21406692
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
T169 Phosphorylation HPRD 20068231
S171 Phosphorylation HPRD 20068231
S173 Phosphorylation HPRD 19413330, 18691976, 19007248, ...17322306, 18669648, 20068231
Y182 Phosphorylation HPRD 18669648, 17081983, 20068231
S187 Phosphorylation HPRD 18691976, 20230923, 19651622, ...18669648, 20166139, 20068231, 17924679
S188 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19691289, 19651622, 18669648, 20068231
S189 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19664994, 19664995, 19007248, 19651622, 18669648, 20068231, 17924679
Y236 Phosphorylation HPRD 16094384
S271 Phosphorylation HPRD 18669648, 20068231
S272 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231, 17924679
K276 Sumoylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S365 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
S169 Phosphorylation HPRD 20068231
Y178 Phosphorylation HPRD 18669648, 17081983, 20068231
S183 Phosphorylation HPRD 18691976, 20230923, 19651622, ...18669648, 20166139, 20068231, 17924679
S184 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19691289, 19651622, 18669648, 20068231
S185 Phosphorylation HPRD 18691976, 17081983, 20230923, ...19664994, 19664995, 19007248, 19651622, 18669648, 20068231, 17924679
Y232 Phosphorylation HPRD 16094384
S267 Phosphorylation HPRD 18669648, 20068231
S268 Phosphorylation HPRD 18669648, 20068231, 17924679
S361 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
S169 Phosphorylation HPRD   PhosphoSitePlus 20068231
K172 Ubiquitination PhosphoSitePlus
T175 Phosphorylation HPRD   PhosphoSitePlus 20068231
K181 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
Y195 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
Y201 Phosphorylation HPRD   PhosphoSitePlus 16094384
T209 Phosphorylation PhosphoSitePlus
S236 Phosphorylation HPRD 18669648, 20068231
S237 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231, 17924679
K241 Sumoylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S330 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T179 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
Y205 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
K245 Sumoylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P20963 (CD247) Y142 Q15366 (PCBP2) unknown eFIP 24502978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C109 Y109 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S154 F154 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K245 M245 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S271 R271 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y278 * Biomuta DOID:3571 / liver cancer [ icgc ]
S289 Y289 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R314 C314 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R314 H314 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R314 L314 Biomuta DOID:3571 / liver cancer [ icgc ]
R314 S314 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S340 T340 Biomuta DOID:363 / uterine cancer [ tcga ]
S340 Y340 Biomuta DOID:184 / bone cancer [ icgc ]
S364 I364 Biomuta DOID:3571 / liver cancer [ icgc ]